Synthesis and Evaluation of Antiinflammatory, Analgesic and Ulcerogenic Potential of NSAIDs Bearing 1,3,4-Oxadiazole Scaffold |
| |
| Authors: | R. R. Somani U. V. Bhanushali |
| |
| Affiliation: | Department of Pharmaceutical Chemistry, VES''s College of Pharmacy, Collector Colony, Chembur, Mumbai, India;1Department of Pharmaceutical Chemistry, Bharati Vidyapeeth''s College of Pharmacy, Sector 8, C.B.D., Navi Mumbai–400 614, India |
| |
| Abstract: | Synthesis of 1,3,4-oxadiazole derivatives of diclofenac and mefenamic acid are described. The target compounds 5-[2-(2,6-dichloroanilino)benzyl]-2-aryl-1,3,4-oxadiazole (3a-3e) and 5-[2-(2,3-dimethylanilino)phenyl]-2-(aryl)-1,3,4-oxadiazole (6a-6e) were obtained by treating 2 and 5 with various aromatic acids using POCl3 as dehydrating agent. They were purified and characterized by IR, 1H-NMR and elemental analysis. These compounds were further subjected to antiinflammatory, analgesic and acute ulcerogenic activity. Compound 3c and 6d exhibited good antiinflammatory activity and compounds 3c, 3e, 6c, 6d, 6e were found to be non ulcerogenic. |
| |
| Keywords: | Analgesic antiinflammatory diclofenac mefenamic acid ulcerogenic activity 1 3 4-oxadiazole |
|
|
