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| Effect of Helicobacter pylorieradication on gastric hyperplastic polyposis in Cowden＇s disease | |
| 引用本文： | Isomoto H,Furusu H,Ohnita K,Takehara Y,Wen CY,Kohno S. Effect of Helicobacter pylorieradication on gastric hyperplastic polyposis in Cowden＇s disease[J]. World journal of gastroenterology : WJG, 2005, 11(10): 1567-1569. DOI: 10.3748/wjg.v11.i10.1567 |
| 作者姓名： | Isomoto H Furusu H Ohnita K Takehara Y Wen CY Kohno S |
| 作者单位： | Second Department of Internal Medicine,Second Department of Internal Medicine,Second Department of Internal Medicine,Second Department of Internal Medicine,Second Department of Internal Medicine Nagasaki University School of Medicine 1-7-1 Sakamoto,Nagasaki,Japan,Nagasaki University School of Medicine 1-7-1 Sakamoto,Nagasaki,Japan,Nagasaki University School of Medicine 1-7-1 Sakamoto,Nagasaki,Japan,Nagasaki University School of Medicine 1-7-1 Sakamoto,Nagasaki,Japan,Nagasaki University School of Medicine 1-7-1 Sakamoto,Nagasaki,Japan |
| 摘 要： | A 21-year-old woman with complaints of hematochezia was diagnosed as having Cowden's disease (CD), an autosomal dominant condition characterized by multiple hamartomas, since facial papules and gingival papillomas were identified. On endoscopy, multiple hyperplastic polyps were seen in the rectum and left-side colon. There were also esophageal glycogenic acanthosis and hyperplastic polyposis in the antrum accompanied by Helicobacter pylori-related gastritis. Although gastric hyperplastic polyposis had by no means regressed with unsuccessful first-line eradication therapy for H pylori, following cure of the infection with salvage therapy consisting of rabeprazole, amoxicillin and metronidazole, the polyposis lesions almost disappeared. Follow-up gastroscopy 2 and 3 years after cessation of the second-line eradication therapy revealed almost complete regression of the polyposis lesions with no evidence of H pylori infection. We recommend eradication treatment for CD patients with gastric hyperplastic polyps and the infection, as the occurrence of gastric carcinoma among hyperplastic polyps has been described. |
| 关 键 词： | 幽门螺旋杆菌 胃增生性息肉 考登氏病 传染病 |
| 收稿时间： | 2004-08-14 |
Effect of Helicobacter pylori eradication on gastric hyperplastic polyposis in Cowden's disease |
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| Isomoto Hajime,Furusu Hisashi,Ohnita Ken,Takehara Yusuke,Wen Chun-Yang,Kohno Shigeru. Effect of Helicobacter pylori eradication on gastric hyperplastic polyposis in Cowden's disease[J]. World journal of gastroenterology : WJG, 2005, 11(10): 1567-1569. DOI: 10.3748/wjg.v11.i10.1567 | |
| Authors: | Isomoto Hajime Furusu Hisashi Ohnita Ken Takehara Yusuke Wen Chun-Yang Kohno Shigeru |
| Affiliation: | 1. Second Department of Internal Medicine,Nagasaki University School of Medicine 1-7-1 Sakamoto, Nagasaki,Japan 2. Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine,Sakamoto 12-4, Nagasaki, Japan;Department of Digestive Disease, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu Province,China |
| Abstract: | A 21-year-old woman with complaints of hematochezia was diagnosed as having Cowden's disease (CD), an autosomal dominant condition characterized by multiple hamartomas, since facial papules and gingival papillomas were identified. On endoscopy, multiple hyperplastic polyps were seen in the rectum and left-side colon. There were also esophageal glycogenic acanthosis and hyperplastic polyposis in the antrum accompanied by Helicobacter pylori-related gastritis. Although gastric hyperplastic polyposis had by no means regressed with unsuccessful first-line eradication therapy for H pylori, following cure of the infection with salvage therapy consisting of rabeprazole, amoxicillin and metronidazole, the polyposis lesions almost disappeared. Follow-up gastroscopy 2 and 3 years after cessation of the second-line eradication therapy revealed almost complete regression of the polyposis lesions with no evidence of H pylori infection. We recommend eradication treatment for CD patients with gastric hyperplastic polyps and the infection, as the occurrence of gastric carcinoma among hyperplastic polyps has been described. |
| Keywords: | Cowden's disease Helicobacter pylori Hyperplastic polyposis |
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