直肠癌低位前切除术后吻合口瘘和肿瘤复发转移的相关性分析

目的探讨直肠癌低位前切除术后吻合口瘘和肿瘤复发转移的相关性。方法选择1999年1月—2006年12月在河南省肿瘤医院行直肠癌低位前切除术患者846例,回顾性分析其临床及病理资料。分析吻合口瘘和肿瘤复发转移的相关性关系。结果吻合口瘘组复发转移率及生存率皆低于对照组。结论直肠癌前切除术后吻合口瘘是肿瘤复发转移的高危因素。

Association between Anastomotic Leak after Anterior Resection of Colorectal Cancer and Local Recurrence or Metastasis

Objective To analyze the association of colorectal anastomotic leakage with tumor recurrence or metastasis.Methods Totally 846 patients received anterior resection during the period January 1999 to December 2006 were studied,among them 48 cases suffered anastomotic leakage.The effect of anastomotic leakage on five-year survival and local recurrence was analyzed using Kaplan-Meier curves and the log-rank test.Results Totally 48 patients suffered anastomotic leakage.Local recurrence： 31.25 percent in the leak group,and 21.68 percent in the nonleak group（P=0.018）.There was significant difference five-year survival and disease free survival between the leak and nonleak groups.Conclusion After rectal anastomosis,an anastomotic leak is associated with a significant increase in local recurrence or metastasis.