| Graves病患者治疗前、后血清甲状腺刺激抗体和TSH结合抑制免疫球蛋白活性的观察 |
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| 引用本文： | 应峰,刘超,蒋须勤,覃又文,刘翠萍,陈家伟,张忠邦.Graves病患者治疗前、后血清甲状腺刺激抗体和TSH结合抑制免疫球蛋白活性的观察[J].标记免疫分析与临床,1996(1). |
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| 作者姓名： | 应峰 刘超 蒋须勤 覃又文 刘翠萍 陈家伟 张忠邦 |
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| 作者单位： | 南京医科大学第一附属医院内分泌科 |
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| 摘 要： | 本文研究了Ｇｒａｖｅｓ病（ＧＤ）患者在抗甲状腺药物（ＡＴＤ）治疗前、后血清甲状腺刺激抗体（ＴＳＡｂ）和ＴＳＨ结合抑制免疫球蛋白（ＴＢＩＩ）的变化，发现治疗前ＴＳＡｂ和ＴＢＩＩ的检出率分别为９１．７％和７９．２％，治疗后两抗体的活性及阳性率均显著下降，表明抗甲状腺药可改善ＧＤ患者的免疫异常。ＴＳＡｂ和ＴＢＩＩ活性不相关，提示ＴＳＨ受体抗体（ＴＲＡｂ）具有异质性。ＴＳＡｂ和ＴＢＩＩ活性与血清甲状腺激素水平无相关关系，说明体外测定的ＴＳＡｂ或／和ＴＢＩＩ活性并不能完全反映甲亢的严重程度。
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| 关 键 词： | 甲状腺肿．突眼性，甲状腺拮抗剂，自身抗体／甲状腺，抗体．TSH受体 |
Study of Thyroid Stimulating Antibody and TSH-Binding Inhibition Immunoglobulin in Patients With Graves' Disease Before and After Therapy |
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| Ying Feng,Liu Chao,Jiang Xuqin,et al..Study of Thyroid Stimulating Antibody and TSH-Binding Inhibition Immunoglobulin in Patients With Graves'''' Disease Before and After Therapy[J].Labeled Immunoassays and Clinical Medicine,1996(1). |
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| Authors: | Ying Feng Liu Chao Jiang Xuqin |
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| Abstract: | Thyroid stimulating antibody (TSAb) and TSH binding inhibition immunoglobulin (TBII) were measured in patients with Graves disease.TSAb and TBII were detected in 91.7%(22/24) and 79.2%(19/24) of patients, respectively before treatment.Both the activities and positivity were significantly reduced after antithyroid drug (ATD)therapy,suggesting that it exerted immunosuppresive effect on the patients. No correlation was found between TSAb and TBII activities,indicating the existence of heterogeneous population of TSH receptor antiboby. TSAb and/or TBII activities might not entirely reflect the severity of hyperthyroidism because of the absence of correlation between the activities and thyroid hormone levels. |
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| Keywords: | Goiter exophthalmic Thyroid antagonists Autoantibodies/thyroid Antibodies TSH receptor |
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