诺和锐30强化治疗对初诊2型糖尿病患者血糖及胰岛功能的影响

目的探讨诺和锐30强化治疗对初诊2型糖尿病患者血糖及胰岛功能的影响。方法对40例初诊2型糖尿病患者进行2周的诺和锐30治疗，分析治疗前后空腹血糖（FPG）及餐后2h血糖（2hPG）、糖化血红蛋白（HbAlc）、静脉葡萄糖耐量试验第一时项胰岛素及C肽分泌和胰岛素及C肽曲线下面积、胰岛素抵抗指数、胰岛素分泌指数、胰岛素敏感指数、空腹胰岛素（FINS）与FPG比值。结果诺和锐30治疗后，FPG、2hPG、HbAlc、胰岛素抵抗指数均较治疗前明显下降（P〈0．01）；窄腹及第一时项胰岛素和C肽的分泌、胰岛素及C肽曲线下面积、FINS与FPG比值、胰岛素分泌指数、胰岛素敏感指数均较治疗前明显升高（P〈0．01）。结论诺和锐30强化治疗能显著改善初诊2型糖尿病患者的血糖及胰岛功能。

Insulin aspart 30 intensive treatment on plasma glucose and pancreatic function in newly diagnosed type 2 diabetic patients

Objective To explore the effect of insulin aspart 30 intensive treatment on plasma glucose and pancreatic function in newly diagnosed type 2 diabets.Methods Forty patients with newly diagnosed type 2 diabetes were treated by 2 weeks insulin aspart 30 treatment.The level of fasting plasma glucose(FPG),2 hours postprandial glucose(2hPG),glycosylated hemoglobin Alc(HbAlc),the first-phase secretion of insulin and C-peptide,the mean area under the curve(AUC) of insulin and C-peptide,insulin resistance index(HOMA-A),insulin secretion index(HOMA-B),insulin sensitivity index(ISI) and the ratio of fasting insulin to fasting glucose(FINS/FPG)were compared before and after insulin aspart 30 treatment.Results After the treatment,FPG(18 vs 6.5mmol/L),2hPG(26 vs 9mmol/L),HbAlc(12% vs 10%)and HOMA-A(0.35 vs 0.26)were significantly decreased(all P<0.01);fasting and the first-phase secretion of insulin and C-peptide,AUC of insulin(AUC_(ins)),FINS/FPG,HOMA-B and ISI greatly increased(all P<0.01).Conclusion Insulin aspart 30 intensive treatment can effectively improve plasma glucose and pancreatic function in newly diagnosed type 2 diabetes.