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| 反相离子对色谱法测定羧甲司坦片和口服溶液中羧甲司坦的含量 | |
| 引用本文： | 赵雪梅,杨颖,黎志芳. 反相离子对色谱法测定羧甲司坦片和口服溶液中羧甲司坦的含量[J]. 中国药品标准, 2000, 1(2): 37-39 |
| 作者姓名： | 赵雪梅 杨颖 黎志芳 |
| 作者单位： | 广州市药品检验所 510160(赵雪梅，杨颖)，广州市药品检验所 510160(黎志芳) |
| 摘 要： | 目的：建立反相离子对色谱法，测定羧甲司坦片和口服溶液中羧甲司坦的含量。方法：采用C18柱，以含0.05％庚烷磺酸钠的0.05mol/L磷酸二氢钾溶液(用磷酸调pH2.5)为流动相．检测波长215nm。结果；该方法羧甲司坦片剂和口服溶液的回收率分别为100.3％．RSD=0.54%(n=5)．100.5%．RSD=0.70％(n=5)。结论；该法准确．可靠．专一性强，能满足制剂质量标准的要求。 |
| 关 键 词： | 反相离子对色谱法 测定 羧甲司坦片 口服溶液 羧甲司坦 含量 |
DETERMINATION OF CARBOCISTEINE IN CARBOCISTEINE TABLETS AND ORAL SOLUTION BY REVERSED ION-PAIR PHASE HPLC |
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| Zhao Xuemei,Yang Ying and Li Zhifang. DETERMINATION OF CARBOCISTEINE IN CARBOCISTEINE TABLETS AND ORAL SOLUTION BY REVERSED ION-PAIR PHASE HPLC[J]. , 2000, 1(2): 37-39 | |
| Authors: | Zhao Xuemei Yang Ying Li Zhifang |
| Affiliation: | Guangzhou Intitute for Drug Control, Guangzhou 510160;Guangzhou Intitute for Drug Control, Guangzhou 510160;Guangzhou Intitute for Drug Control, Guangzhou 510160 |
| Abstract: | Objective: A Reversed ion-pair phase HPLC method has been studied to determine the contents of carbocisteine in Carbocisteine Tablets and Oral solution.Method: The chromatographic condion are Listed below:C18column,detection wavelength 215 nm,and a mobile phase 0.05mol/L K2HPO4(containing 0.05% Sodium heptanesulfonate and pH ajuested to 2.5 with phosphovic scid),Results: The recoveries for Carbocisteine Tablets and Oral solution in the method are 100.3% (RSD0.54%,n=5).and 100.5%(RSD=0.70%,n=5),respectively.Conclusion: The method is simple,rapid and reliable. |
| Keywords: | Reversed ion pair phase HPLC Carbocisteine |
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