Discriminative value of serum amyloid A and other acute-phase proteins for coronary heart disease |
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Authors: | Delanghe Joris R Langlois Michel R De Bacquer Dirk Mak Rudolf Capel Paul Van Renterghem Lieve De Backer Guy |
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Affiliation: | a Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium b Department of Public Health, Ghent University Hospital, Ghent, Belgium c Department of Medical Chemistry, Erasmus Hospital, Brussels Free University, Brussels, Belgium |
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Abstract: | We studied the value of serum amyloid A (SAA), a first-class acute-phase protein, as a marker for coronary heart disease (CHD) in a middle-aged male population. In a working population of 16 307 men (age, 35–59 years), 446 cases had a history of CHD or prominent Q:QS waves on electrocardiogram. For each case, two matched controls were investigated. SAA, measured by immunonephelometry, was correlated with other acute-phase proteins, cardiovascular risk factors, and infectious serology markers. SAA concentrations were significantly higher in the cases than in controls (P<0.05) and correlated with serum C-reactive protein (CRP) (r=0.61), plasma fibrinogen (r=0.39), serum haptoglobin (r=0.26), and body mass index (r=0.13) (P<0.001). Serum CRP is a better marker for CHD than SAA, which showed discriminative power only in a univariate model comparing highest versus lowest tertile (odds ratio, 1.39; 95% confidence interval, 1.03–1.87). Neither SAA nor other acute-phase proteins correlated with Chlamydia pneumoniae immunoglobulin (Ig)G, Helicobacter pylori IgG and IgA, and cytomegalovirus IgG. In conclusion, although SAA has a discriminative value for CHD, serum CRP is to be preferred as a first-class acute-phase reactant for detection of the disease. |
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Keywords: | Serum amyloid A C-Reactive protein Acute-phase proteins Inflammation Coronary heart disease |
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