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Giant Cell Interstitial Pneumonia Associated with Nitrofurantoin |
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| Authors: | Charles William Hargett Thomas A. Sporn Victor L. Roggli John W. Hollingsworth |
| Affiliation: | (1) Division of Pulmonary, Allergy, and Critical Care, Duke University Medical Center, Box 3221, Durham, NC 27710, USA;(2) Department of Pathology, Duke University Medical Center, Box 3712, Durham, NC 27710, USA;(3) Division of Pulmonary, Allergy, and Critical Care, Duke University Medical Center, Box 3136, Durham, NC 27710, USA |
| Abstract: | A case of giant cell interstitial pneumonia (GIF) that occurred in association with exposure to nitrofurantoin is presented. While the diagnosis of GIP is confirmed by histopathology, this diagnosis can be supported by the findings of bizarre multinucleated giant cells (MGC), elevated T lymphocytes, and a low T lymphocyte helper/suppressor ratio in the bronchoalveolar lavage fluid (BALF). Recognition of GIP as a rare manifestation of nitrofurantoin toxicity is important because prompt therapy may be associated with a favorable outcome. This work was supported by the National Institute of Environmental Health Sciences (ES12717). |
| Keywords: | Lung diseases Interstitial Nitrofurantoin Drag toxicity Giant cells Metals heavy |
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