阿米洛利的神经保护作用

阿米洛利是一种上皮细胞钠离子通道(ENaC)阻滞药,作为一种保钾利尿药已在临床应用了数十年.研究表明,中枢神经系统的多种离子通道对阿米洛利敏感,如酸敏感离子通道(ASIC)、Na+/H+交换泵等.这些通道具有重要的生理功能,而且还可能参与了脑缺血、组织酸中毒等病理学过程.阿米洛利通过阻滞这些通道,呈现出减轻缺血和酸化介导的神经元损伤等效应,很有可能成为治疗脑缺血等的新型神经保护剂.

Neuroprotective Effects of Amiloride

Amiloride is an epithelial Na+ channel(EnaC)blocker.As a potassium-sparing diuretic,it has been used in clinical practice for decades of years.Studies have shown that many ion channels were semitive to amiloride in the central nervous system,such as acid-sensitive ion channel(ASIC)and Na+/H+ exchanger.These channels have important physiological functions,and paticipate in pathological processes such as cerebral ischemia and tissue acidosis.It has demonstrated that amailoride reduces the effects of ischemia-and acid-mediated neuronal injury by blocking these channels,which may become a novel neuroprotective agent for the treatment of cerebral ischemia.