外源性肺泡表面活性物质治疗急性肺损伤的研究进展

现代医学认为,急性肺损伤(acute lung injury,ALI)是由各种原因产生肺呼吸膜弥漫性损伤导致气体交换障碍而引起的综合征,临床上主要表现为进行性氧分压下降和难以纠正的低氧血症.ALI时,肺泡上皮细胞受损,使内源性肺泡表面活性物质(pulmonary surfactant,PS)合成数量下降,功能降低,而内源性PS结构和功能的失常反过来又可进一步加重肺功能损害,形成恶性循环.使用外源性PS可以弥补ALI时内源性PS的数量减少和功能降低,从而达到治疗ALI的目的.本文对近几年外源性PS治疗ALI的相关研究进行整理综述.

Research progress of exogenous pulmonary surfactant treatment on acute lung injury

In modern medicine,it is believed that acute lung injury(ALI) is a syndrome that diffusive damage of respiratory membrane induced by all kinds of reasons causes gas exchange disorder. Its clinical performances are mainly progressive degression of partial pressure of oxygen and hyoxemia corrected difficultly. In ALI, damage of alveolar epithelial cell can decrease synthesis of endogenous pulmonary surfaetant (PS) and reduce its function,which aggravates damage of lung function and forms vicious cycle. Exogenetic PS can retrieve decrease of endogenous PS and reduction of its function, and treat ALL The summary is about the correlative research about ALI treatment with exogenetic PS in recent years.