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| 氯沙坦对糖尿病大鼠腹主动脉超微结构的影响 | |
| 引用本文： | 徐勇,郑富蓉,马红艳,杨军,肖斌,周英,雷贤英. 氯沙坦对糖尿病大鼠腹主动脉超微结构的影响[J]. 泸州医学院学报, 2004, 27(1): 17-19 |
| 作者姓名： | 徐勇 郑富蓉 马红艳 杨军 肖斌 周英 雷贤英 |
| 作者单位： | 1. 泸州医学院附属医院内分泌科,四川泸州,646000 2. 泸州医学院电镜室,四川泸州,646000 3. 泸州医学院生化教研室,四川泸州,646000 |
| 基金项目： | 四川省卫生厅科研基金项目 (2 0 0 0 - 0 0 0 12 4 ) |
| 摘 要： | 目的 :探讨糖尿病大鼠腹主动脉超微结构改变及血管紧张素Ⅱ受体拮抗剂 (ATR)氯沙坦对其影响。方法 :将健康的Wistar大鼠 30只随机分为正常对照组 (NC)、糖尿病对照组 (DC)、糖尿病氯沙坦治疗组 (DL) ,每组各10只。用链脲佐菌素 6 0mg kg腹腔注射复制糖尿病模型 ,造模后第 2天起DL组每天给予氯沙坦 2 0mg kg ,每周监测血糖 ,4周末取腹主动脉作电镜观察。结果 :DC、DL组血糖明显升高 ,4周后电镜显示 ,DC组腹主动脉逐渐出现内皮细胞肿胀、内弹力层中断 ,并出现平滑肌细胞 (SMC)伸入内膜 ,而DL组病变明显减轻。结论 :4周糖尿病大鼠腹主动脉即出现超微结构改变 ,氯沙坦能改善这种病理变化 ,ATR对糖尿病大鼠腹主动脉可能有一定保护作用 |
| 关 键 词： | 氯沙坦 糖尿病 超微结构 腹主动脉 |
| 文章编号： | 1000-2669(2004)1-017-03 |
| 修稿时间： | 2003-09-11 |
THE EFFECT OF LOSARTAN ON ULTRASTRUCTURE OF AORTA IN DIABETIC RATS |
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| Xu Yong,et al. THE EFFECT OF LOSARTAN ON ULTRASTRUCTURE OF AORTA IN DIABETIC RATS[J]. Journal of Luzhou Medical College, 2004, 27(1): 17-19 | |
| Authors: | Xu Yong et al |
| Affiliation: | Xu Yong,et al Department of Endocrinology,Luzhou Medical College Hospital |
| Abstract: | Objective:To investigate the effect of Losartan on ultrastructure of the aorta in diabetic rats. Methods: Wistar rats were randomly divided into normal control group(NC),diabetes control group(DC), and diabtes treated with Losartan group(20 mg/kg.d)(DL).At 4 weeks after treatment, aortas were observed by electron microscope. Results:In DC group, there were edemas in the aortic endothelial cells, breakage of internal elastic lamina,and smooth muscle cells migrating into intima at 4 weeks. In DL group, the changes were abated significantly compared with DC group. Conclusion: Losartan can improve pathological changes of ultrastrucure in diabetic rats and protect the aorta of diabetes. |
| Keywords: | Losartan Diabetes Aorta Ultrastructure |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |