男性不育不同证型用药规律分析

目的总结男性不育不同证型的中药用药规律。方法检索CNKI《中国期刊全文数据库》收录的发表于2002—2012年与男性不育中药治疗相关文献，建立数据库，通过中医药关联分析数据软件，分析男性不育不同证型肾阳虚型、肾阴虚型、湿热蕴结型、脾肾阳虚型、阴虚火旺型用药规律。结果在5种不同证型的男性不育用药前20位中，共涉及用药61味，其中补药28味，清热药12味，利水渗湿药8味，活血药5味，收涩药3味，温里药2味，祛风湿药1味，开窍药1味。核心用药有：在男性不育五种证型中均用药：淫羊藿、熟地黄、菟丝子、山茱萸、山药；四种证型中均用药：茯苓、肉苁蓉、车前子；在三种证型中均用药枸杞子、当归、生地黄、五味子、鹿茸、黄芪、黄柏、知母等。结论治疗男性不育中药方剂较多，但用药主要集中在滋补、清热、养血、活血、利湿等几类，用药遵循补泻兼用、阴阳互补、扶正祛邪的原则。

Study on the Medical Features in the Treatment of Different Syndromes of Male Infertility

Objective To summarize the medical features of traditional Chinese medicine in the treatment of male infertility. Methods The retrieval was conducted in China National Knowledge Infrastructure （CNKI） database. The key words were set as traditional chinese medicine, ＇male infertility＇ and ＇treatment＇. The available data was defined between 2002 and 2012. The qualified literatures were categorized and extracted to integrate a database, and the software oftraditional Chinese medicine correlation analysis was applied to analyze the medical features in kidney yang deficiency, kidney yin deficiency, stagnation of damp-heat, spleen kidney yang deficiency and hyperactivity of fire due to yin deficiency. Results In the five categories of male infertility, 61 drugs were involved in the treatment. 28 kinds of those were tonic, 12 kinds of those were antipyretic, 8 kinds of those were diuretic and dampness-excreting, 5 kinds of those were related to activation of blood, 3 kinds of those were astringent, 2 kinds of those were inner-warming and 1 of those were anti-rheumatism and inducing resuscitation, respectively. The significant medical features were found as follows： epimedium, prepared rhizome of rehmannia, dodder, dogwood and Chinese yam were commonly identified in five male infertility syndromes; poria, cistanche and plantago were commonly identified in four male infertility syndromes; medlar; angelica; radix rehmanniae; schisandra chinensis; antler; astragalus root; phellodendron bark and anemarrhena were commmonly identified in three male infertility syndromes. Conclusion Various kinds of traditional Chinese medicine formulae were applied in the treatment of male infertility, furthermore, most of them were concentrated in categories of tonic, antipyretic, nourishing and activating blood and removing dampness, which gave consideration to reinforcing and reducing, reinforcing yin and yang complementarily and strengthening healthy qi to eliminate pathogens.