神经节苷脂治疗吉兰-巴雷综合征疗效及肌电图变化的临床评价

目的:评价神经节苷脂在促进吉兰-巴雷患者恢复方面上的临床疗效及肌电图变化。方法:将符合入选标准的36例患者随机分为2组,分别采用神经节苷脂和普通B族维生素治疗。治疗前后对两组患者定期进行MRC、Hughes评分以及肌电图检查,测定运动神经传导速度及F波平均潜伏期。结果:两组MRC、Hughes评分与治疗前相比均有显著或极显著差异(P<0.05-0.01),半年后两组MRC、Hughes评分比较有显著差异(P<0.05),半年后两组运动神经传导速度、F波潜伏期比较有显著差异(P<0.05),两组无明显不良反应。结论:神经节苷脂是促进吉兰-巴雷患者恢复的有效药物,无论是临床评分还是肌电图改善均优于普通B族维生素。

Assessment of curative effects and changes in EMG of monosialote trahexosyl ganglioside for Guillain-Barre syndrome

Objective: To assess the clinical effects and the changes in EMG of monosialote trahexosyl ganglioside for improving the recovery of Guillain-Barre syndrome. Methods: 36 patients who conformed with the standard were randomly divided into two groups and treated with monosialote trahexosyl ganglioside or B-group vitamin, respectively. The scores MRC and Hughes were used to evaluate the neurological deficits and EMG was used to determine the MCV and F-latency of the two groups regularly before and after treatment,. Results: There was a significant or more significant difference in the scores before and after treatment(P<0.05-0.01); there was a significant difference in the scores and in the MCV and F-latency between the two groups after half one year, no distinct adverse reaction happened in the two groups. Conclusion: The monosialote trahexosyl ganglioside is a effective medicine for improving the recovery of Guillain-Barre syndrome,and it is superior to the B-group vitamin no matter in the scores or in EMG.