| 大鼠吗啡依赖形成过程中免疫活性强啡肽A1—13的含量 |
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| 引用本文： | 万兴旺 黄矛. 大鼠吗啡依赖形成过程中免疫活性强啡肽A1—13的含量[J]. 中国药理学报, 1998, 19(6): 560-563 |
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| 作者姓名： | 万兴旺 黄矛 |
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| 摘 要： | ![]()
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| 关 键 词： | 强啡肽类 放射免疫测定 药物依赖 |
Levels of immunoreactive dynorphin A1-13 during development of morphine dependence in rats. |
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| X W Wan,W H Li,M Huang,Z D You,Y X Tan,C L Lu,Z H Gong. Levels of immunoreactive dynorphin A1-13 during development of morphine dependence in rats.[J]. Acta Pharmacologica Sinica, 1998, 19(6): 560-563 |
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| Authors: | X W Wan W H Li M Huang Z D You Y X Tan C L Lu Z H Gong |
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| Affiliation: | Research Laboratory of Natural and Synthetic Drugs, College of Pharmacy, Second Military Medical University, Shanghai, China. |
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| Abstract: | ![]()
AIM: To study the relationship between the levels of immunoreactive dynorphin A1-13 (ir-dynorphin A1-13) and the degree of morphine dependence. METHODS: The levels of ir-dynorphin A1-13 in discrete brain regions, spinal cord, and plasma in rats were determined by radioimmunoassay, and the degree of morphine dependence was assessed by scoring withdrawal signs on d 3, d 6, and d 12. RESULTS: Morphine injection s.c. decreased the levels of ir-dynorphin A1-13 in spinal cord, pituitary, and plasma. The levels of ir-dynorphin A1-13 in hippocampus and hypothalamus were increased. No changes in cortex, midbrain, cerebellum, pons, and medulla were observed. With continuous injection of morphine, withdrawal signs scores were increased on d 6, but there was no difference between the scores of d 6 and d 12. CONCLUSION: The changes of the levels of endogenous ir-dynorphin A1-13 in pituitary, spinal cord, and plasma were compatible with the degree of morphine dependence. |
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