| 盐藻β—胡萝卜素抗突变效应 |
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| 引用本文： | 马国建 袁生. 盐藻β—胡萝卜素抗突变效应[J]. 中国药理学报, 1998, 19(3): 282-284 |
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| 作者姓名： | 马国建 袁生 |
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| 摘 要： |
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| 关 键 词： | β胡萝卜素 杜氏盐藻 抗突变效应 |
Antimutagenic effects of beta-carotene from Dunaliella salina] |
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| G J Ma,K X Xue,J Z Wu,S Yuan,H L Qin. Antimutagenic effects of beta-carotene from Dunaliella salina][J]. Acta Pharmacologica Sinica, 1998, 19(3): 282-284 |
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| Authors: | G J Ma K X Xue J Z Wu S Yuan H L Qin |
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| Affiliation: | Jiangsu Institute of Cancer Research, Nanjing, China. |
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| Abstract: | AIM: To study the genotoxic and antimutagenic efficts of beta-carotene from Dunaliella salina (beta-CDS). METHODS: The in vitro micronucleus and chromosomal aberration tests in hunman lymphocytes were adopted. The effect of beta-CDS on mutagensis induced by gamma-rays and mitomycin (Mit) was studied. RESULTS: beta-CDS (1-30 mg.L-1) had no genotoxicity, but inhibited spontaneous and gamma-ray-induced micronucleus fromation and Mit-induced chromosomal aberrations in human lymphocytes in vitro. The genotoxic action of synthetic beta-carotene (S beta C) was suppressed, the antimutagenic effects were heightened when S beta C and beta-carotene oil (beta CO, one of the beta-CDS compositions) were mixed in proportion as 80:27.5. CONCLUSION: beta-CDS is an antimutagenic agent. |
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