| 促皮质素对甲醛引起大鼠脊髓c—fos表达的影响及受体分析 |
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| 引用本文： | 黎海蒂 李希成. 促皮质素对甲醛引起大鼠脊髓c—fos表达的影响及受体分析[J]. 中国药理学报, 1998, 19(4): 394-396 |
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| 作者姓名： | 黎海蒂 李希成 |
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| 摘 要： | ![]()
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| 关 键 词： | 促皮质素 c－fos 甲醛 脊髓 免疫组化 |
Effect of corticotropin on formalin-evoked c-fos expression of spinal cord and receptors analysis in rat] |
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| H D Li,X C Li,H Z Ruan. Effect of corticotropin on formalin-evoked c-fos expression of spinal cord and receptors analysis in rat][J]. Acta Pharmacologica Sinica, 1998, 19(4): 394-396 |
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| Authors: | H D Li X C Li H Z Ruan |
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| Affiliation: | Department of Physiology, Third Military Medical College, Chongqing, China. |
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| Abstract: | ![]()
AIM: To study the effect of corticotropin (Cor) on c-fos expression induced by formalin in spinal cord of rat and the role of receptors. METHODS: Using immunohistochemistry and adrenalectomy. RESULTS: Cor inhibited the formalin-evoked c-fos expression in rat spinal cord in a dose-dependent manner. No obvious effect was seen by i.p. Cor 10 U.kg-1, but 25 U.kg-1 reduced the evoked c-fos expression, that was blocked by phentolamine, naloxone, or verapamil, but not much changed by adrenalectomy. CONCLUSION: The formalin-evoked c-fos expression of rat spinal cord was suppressed by Cor through the alpha-adrenergic receptors, opiate receptors and calcium, but no relation to adrenal glands. |
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