急性颅脑损伤患者内皮素含量变化及临床意义

目的：探讨急性颅脑损伤患者内皮素含量变化的意义。方法：采用放免法动态测定53例急性颅脑损伤患者血浆及脑脊液内皮素含量，以观察内皮素水平在颅脑损伤组和正常对照组中的变化。结果：颅脑损伤患者急性期血浆及脑脊液内皮素含量显著高于对照组，且与病情轻重程度明显相关。结论：内皮素参与急性颅脑损伤后继发性病理生理损害，钙拮抗剂成为治疗颅脑损伤的有效途径，血浆或脑脊液内皮素动态含量，可能是判断颅脑损伤患者预后的重要因素。

EVALUATION ON THE CHANGES OF ENDOTHELIN IN PATIENTS WITH ACUTE CRANIOCEREBRAL TRAUMA

Aim: To evaluate the changes of Endothelin (ET) in patients with acute craniocerebral trauma.Methods: The contents of ET in plasma and CSF in 53 patients with acute craniocerebral trauma were determined dynamically by radioimmunoassay, in order to observe the changes of ET leve1s in craniocerebral trauma and normal contrast group. Results: ET levels in plasma and CSF on the acute period in craniocerebral trauma group were significantly higher than that in the controlled. These changs correlated with the severity of the injury. Conclusion:The results indicated that ET can cause secondary pathophysiologic injury following acute craniocerebral trauma.The findings supported that Ca2 antagonist may be useful in the treatment of craniocereoral trauma. ET levels in plasma and CSF after craniocerebral trauma might be important prognostic factors affecting the outcome in the patients with craniocerebral trauma.