| Runx3基因启动子区甲基化与胃癌的关系 |
| |
| 引用本文： | 李青,赵丽珍,王永福,郭春林. Runx3基因启动子区甲基化与胃癌的关系[J]. 中国实验诊断学, 2007, 11(2): 152-154 |
| |
| 作者姓名： | 李青 赵丽珍 王永福 郭春林 |
| |
| 作者单位： | 包头医学院第一附属医院,基因诊断中心,内蒙古,包头,014010 |
| |
| 摘 要： | 目的通过检测胃癌Runx3基因启动子区域甲基化状态，来探讨Runx3基因启动子区域甲基化在胃癌发生和发展过程中的临床意义。方法采用DNA甲基化特异性PCR（MSP）技术对37例胃癌患者手术切除肿瘤组织及其癌旁组织Runx3基因启动子区域甲基化进行检测。结果Runx3基因在37例胃癌及其癌旁组织中甲基化率分别为40．5％（15／37）和8％（3／37）。结论Runx3基因启动子区甲基化可能是肿瘤特异性的（P＜0．05），可作为胃癌早期诊断的分子标记物。
|
| 关 键 词： | 胃癌 甲基化 Runx3基因 |
| 文章编号： | 1007-4287（2007）02-0152-03 |
| 收稿时间： | 2006-06-29 |
| 修稿时间： | 2006-06-29 |
Promoter hypermethylation of Runx3 and P16 in Gastric cancer |
| |
| LI Qing, ZHAO Li-zhen, WANG Yong-fu,et al.. Promoter hypermethylation of Runx3 and P16 in Gastric cancer[J]. Chinese Journal of Laboratory Diagnosis, 2007, 11(2): 152-154 |
| |
| Authors: | LI Qing ZHAO Li-zhen WANG Yong-fu et al. |
| |
| Affiliation: | LI Qing, ZHAO Li-zhen, WANG Yong-fu, et al. |
| |
| Abstract: | Objective To study the clinic significance of Runx3 hypermethylation in gastric cancer,we examined the promoter methylation status of these genes in both neoplastic and non-neoplastic gastric epithelia obtained at surgery.Methods The methylation status of Runx3 was examined by methylation-specific polymerase chain reaction(MSP).Results Among samples obtained from patients with stomach cancer,methylation was observed in both the neoplastic and the corresponding non-neoplastic gastric epithelia,40.2%(15/37) and 8%(3/37) for Runx3,respectively.Conclusion High frequent hypermethylation of Runx3 is mostly cancer specific(P<0.05),and may be utilized as a molecular diagnostic marker of gastric cancer. |
| |
| Keywords: | gastric cancer mythyhtion Runx3 gene |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
