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| GRP78mRNA在食管鳞状细胞癌中的表达 | |
| 引用本文： | 郝鹏程,魏煜程,王冲,任晓峰,李自亨. GRP78mRNA在食管鳞状细胞癌中的表达[J]. 中国卫生产业, 2012, 9(21): 14-15 |
| 作者姓名： | 郝鹏程 魏煜程 王冲 任晓峰 李自亨 |
| 作者单位： | 1. 青岛大学医学院,山东青岛,266000 2. 青岛大学医学院附属医院,山东青岛,266000 3. 山东省荣军总医院,山东济南,250000 |
| 摘 要： | 目的 检测GRP78 mRNA在食管鳞状细胞癌中的表达情况.方法 应用RT-PCR法检测30例食管鳞状细胞癌组织及其癌旁组织中GRP78 mRNA的表达情况.结果 食管鳞状细胞癌组织及癌旁组织中GRP78 mRNA的表达阳性率分别为56.67%(17 /30)和26.67%(8/30),GRP78 mRNA在食管鳞状细胞癌组织中表达水平明显高于癌旁组织.两组差异有统计学意义(P < 0.05).结论 与癌旁组织相比,食管鳞状细胞癌GRP78 mRNA呈现高表达,表明GRP78可能参与了食管鳞状细胞癌的发生过程,可以作为食管鳞状细胞癌的一种有价值的肿瘤分子标志物. |
| 关 键 词： | 食管鳞状细胞癌 GRP78 RT-PCR |
The expression of GRP78 mRNA in esophageal squamous cell carcinoma |
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| HAO Pengcheng , WEI Yucheng , WANG Chong , REN Xiaofeng , LI ziheng. The expression of GRP78 mRNA in esophageal squamous cell carcinoma[J]. China Health Industry, 2012, 9(21): 14-15 | |
| Authors: | HAO Pengcheng WEI Yucheng WANG Chong REN Xiaofeng LI ziheng |
| Affiliation: | 1.Medical College of Qingdao University,Qingdao 266000,China;2 Affiliated Hospital,Medical College of Qingdao University,Qingdao 266000,China;3 Department of Thoracic Surgery,Shandong Rongjun Hospital,Jinan 250013,China |
| Abstract: | Objective To investigate the expression of GRP78 mRNA in esophageal squamous cell carcinoma.Methods The expression of GRP78 mRNA in cancerous tissues and paracancerous tissues from 30 patients with esophageal squamous cell carcinoma were analyzed using RT-PCR analysis.Results GRP78 mRNA was positive in 56.67%(17/30) cancerous tissues and 26.67%(8/30) paracancerous tissues of esophageal squamous cell carcinoma.The expression of GRP78 mRNA was significantly higher(P<0.05) in cancerous tissues compared with paracancerous tissues.Conclusion GRP78 may be involved in the pathogenesis of esophageal squamous cell carcinoma and may be a potential tumor maker of the disease. |
| Keywords: | Esophageal squamous cell carcinoma GRP78 RT-PCR |
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