Paradoxical Role of Helicobacter pylori Infection: Protective Effect Against Ethanol-Induced Gastric Mucosal Injury in Mongolian Gerbils |
| |
| Authors: | Atsushi Sugiyama Tatsuo Ikeno Kimitaka Ishida Fukuto Maruta Maki Murakami Toshiyuki Sato Hiroyasu Saito Satoshi Ishizone Seiji Kawasaki Hiroyoshi Ota† Tsutomu Katsuyama† |
| |
| Institution: | (1) First Department of Surgery, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621 Nagano, Japan;(2) Department of Laboratory Medicine, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621 Nagano, Japan |
| |
| Abstract: | We investigated the effect of ethanol (a representative necrotizing agent) on gastritis induced by Helicobacter pylori infection in Mongolian gerbils. Seventy-eight gerbils were used. Four and 12 weeks after H. pylori inoculation, 30% ethanol was administered into the stomach. The stomachs were removed after 30 min, the intramucosal prostaglandin (PG) E2 concentration was measured, and histopathology was recorded. H. pylori infection caused chronic active gastritis, gastric erosion, hypersecretion of mucin from gland mucus cells, and a rise in the activity of intramucosal PGE2. After ethanol administration, gastric erosion was significantly less in animals infected with H. pylori than in uninfected animals. In conclusion, in the early stage of H. pylori infection, accentuation of intramucosal PGE2 and hypersecretion of mucin from gland mucus cells have a protective effect against gastric mucosal injury induced by necrotizing agents. |
| |
| Keywords: | Helicobacter pylori gastric mucin Mongolian gerbil prostaglandin necrotizing agent ethanol |
| 本文献已被 SpringerLink 等数据库收录！ |
|
