术前NLR、PLR及RDW预测前列腺癌患者术后复发转移的价值

目的:探讨中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)及红细胞分布宽度(red blood cell distribution width,RDW)对前列腺癌(pros-tate...

The value of preoperative NLR,PLR and RDW in predicting postoperative recurrence and metastasis in patients with prostate cancer

Objective:To explore the value of neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR)and red blood cell distribution width(RDW)in the recurrence and metastasis of prostate cancer(PCa)after operation.Methods:128 patients with PCa admitted to our hospital from January 2016 to June 2018 were divided into non-recurrence and metastasis group(n=78)and recurrence and metastasis group(n=50)according to their recurrence and metastasis after operation.The levels of NLR,PLR and RDW in PCa patients were measured by Sysmex XN-3000 automatic hematology analyzer,and their relationship with clinicopathological features was analyzed.Receiver operating characteristic(ROC)curves were used to analyze the value of NLR,PLR and RDW in predicting postoperative recurrence and metastasis of PCa.The correlation among NLR,PLR and RDW was detected by Pearson correlation analysis.Results:The levels of NLR(3.72±1.56 vs 2.38±1.14),PLR(190.82±62.83 vs 158.42±43.70)and RDW[(13.85±1.24)%vs(12.74±0.96)%]in the recurrence and metastasis group were significantly higher than those in the non-recurrence and metastasis group(P<0.01).The levels of NLR,PLR and RDW in patients with recurrence and metastasis were correlated with TNM stage,Gleason score and differentiation degree(P<0.05).ROC curve analysis showed that the best cut-off values of NLR,PLR and RDW for predicting postoperative recurrence and metastasis of PCa were 3.06,181.42,13.28%,respectively.The AUC(0.857,95%CI:0.795~0.916)of postoperative recurrence and metastasis predicted by the three combination was the highest,with the sensitivity and specificity of 87.3%and 82.0%.The correlation analysis showed that NLR was positively correlated with PLR and RDW in patients with recurrence and metastasis(r=0.758,r=0.625,P<0.01),and PLR was positively correlated with RDW(r=0.548,P<0.01).Conclusion:Preoperative higher NLR,PLR and RDW levels are associated with postoperative recurrence and metastasis of PCa,and the three combined test is of certain value in predicting postoperative recurrence and metastasis of PCa patients.