糖尿病肾脏病患者血清Sirt1与炎症及氧化应激反应、白蛋白尿短期进展的关系

目的 研究糖尿病肾脏病(DKD)患者血清沉默信息调节因子1(Sirt1)与炎症及氧化应激反应、白蛋白尿短期进展的关系.方法 回顾性选择2019年6月至2021年6月期间在首都医科大学附属北京友谊医院住院治疗的75例2型DKD患者作为DKD组,取同期就诊的60例单纯2型糖尿病患者作为DM组、体检的60名健康志愿者作为对照...

Relationship between serum Sirt1 and inflammation,oxidative stress,short-term progression of albuminuria in patients with diabetic kidney disease

Objective To investigate the relationship between serum Sirt1 and inflammation,oxidative stress,short-term progression of albuminuria in patients with diabetic kidney disease(DKD).Methods From June 2019 to June 2021,75 type 2 diabetes patients with DKD were selected as DKD group,60 patients with simple type 2 diabetes were selected as DM group,and 60 healthy volunteers were selected as control group.Serum Sirt1,tumor necrosis factor-α(TNF-α),interleukin(IL)-1β,IL-6,8-hydroxydeoxyguanosine(8-OHdG),malondialdehyde(MDA)and total anti-oxidant capacity(T-AOC)were detected.The short-term progress of albuminuria in patients with DKD was followed up.Results The levels of serum Sirt1 of patients in DKD group and DM group were(7.86±2.46)and(10.22±2.95)ng/mL,respectively,which were lower than those in control group(14.17±3.21)ng/mL],and the level of serum Sirt1 of patients in DKD group were lower than those in DM group,and the differences were statistically significant(P<0.05).In DKD group,the level of serum Sirt1 of patients with 24 h urinary albumin>300 mg was(8.51±2.85)ng/mL,which was lower than of patients with 24 h urinary albumin 30-300 mg(6.21±1.84)ng/mL],and the difference was statistically significant(P<0.05).The levels of serum TNF-α,IL-1β,IL-6,MDA,8-OHdG of patients with Sirt1 content≥median were(8.28±1.75)ng/mL,(4.58±0.83)ng/mL,(56.72±9.39)pg/mL,(6.58±1.15)μmol/L,(23.83±6.58)ng/mL,which were lower than that of patients with Sirt1 content