急性冠状动脉综合征患者白细胞介素-10及白细胞介素-6表达

目的:通过与C反应蛋白(CRP)检测对比,探讨抗炎因子白细胞介素(IL)-10、促炎因子IL-6与急性冠状动脉综合征(ACS)的关系。方法:冠心病患者78例,其中ACS患者40例(ACS组),稳定型心绞痛(SAP组)患者38例,33例胸痛综合征(CPS组)患者作为对照。所有患者均行冠状动脉造影检查。采用ELISA法检测血浆IL-6、IL-10水平,采用免疫比浊法测定CRP值。结果:与SAP组及CPS组相比,ACS组血浆IL-10水平明显降低,IL-6、CRP水平明显升高,差异有统计学意义;SAP组IL-10水平低于CPS组,IL-6、CRP水平高于CPS组,差异无统计学意义;血浆IL-10水平与IL-6及CRP水平呈负相关,IL-6水平与CRP水平正相关。结论:血浆IL-10水平降低和IL-6、CRP值升高对患者ACS的发生有预测价值。抗炎因子和促炎因子水平的失衡是导致斑块不稳定、急性冠状动脉事件发生的重要因素。

Plasma levels of the interleukin-10 and interleukin-6 in patient with acute coronary syndrome

Objective:To investigate the relationship between the levels of IL-10,IL-6 and acute coronary syndrome(ACS).Method:Peripheral blood was collected from 40 patients with ACS,38 patients with stable angina pectoris(SAP) and 33 patients with chest pain syndrome(CPS).Plasma levels of IL-10 and IL-6 were measured by ELISA and that of CRP was measured by immunoturbidimetry.Result:IL-10 levels were decreased,while the levels of IL-6 and CRP increased in ACS group,compared with SAP group and CPS group.IL-10 was negatively correlated with the levels of IL-6 and CRP while IL-6 was positively correlated with CRP.Conclusion:The decrease of IL-10 and the increase of IL-6 and CRP are associated with an unfavorable prognosis in patients with ACS.The imbalance of anti-inflammatory and proinflammatory cytokines plays an important role of pathogenesis of plaque instability.