骨碱性磷酸酶检测用于小儿佝偻病筛查

目的　探索本地区小儿佝偻病发病概况与临界佝偻病的早期筛查 ,为社区儿童保健提供相关资料 ,以促进对该病及早采取防治措施。方法　取末梢微量全血 ,应用骨碱性磷酸酶 (BACP)试剂盒 ,检测血浆中BALP活性 ,以判定是否佝偻病。结果　依据佝偻病诊断标准的BALP活性界限值 ,检测显示佝偻病者占 33.91% ,临界佝偻病为 32 .0 5 % ,2岁以下年龄组内男女无明显差异 (P >0 .0 5 ) ,各年龄组之间差异非常显著 (P <0 .0 1)。结论　佝偻病是儿科常见的“四病”之一 ,其发病率高 ,危害儿童健康 ,应用试剂盒检测BALP活性 ,具有用血量少、操作简便、快速、特异性强、灵敏度及准确性高的优点 ,是一种早期诊断佝偻病的实验方法

Bone Alkaline phosphatase Test Screening Rickets of Vitamin D Deficiency in Children

Objectives:To investigate the incidence of vitamin D deficiency rickets in this area,to screen subclinical rickets early,to make reference information for children's community health office so that to pverent this disease early. Methods:Using Bone Alkaline phosphatase (BALP) reagent case to assay BALP activity in a little periheral blood for rickets judging.Results:judged by BALP activity line of rickets.This screening show that there are 33.91% vitmin D deficiency rickets patients and 32.05%subclinical rickets.No significantly difference between male and female under the age of two (P>0.05).But there are significantly difference in among ages (P<0.01) Conclusion:Vitmin D deficiency rickets is one the "the Four Common Disease" in children.This disease has high incident rate. It is a threaten to children's health.Using little blood and operating easily are the advantages of this method and assaying results are specific,sensitive and quickly.It is a good experimental method of screening rickets of vitmin D deficiency early.