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| 海藻酸钠/淀粉复合微球的制备及用于盐酸小檗碱的控制释放研究 | |
| 引用本文： | 江宇良,刘庆林. 海藻酸钠/淀粉复合微球的制备及用于盐酸小檗碱的控制释放研究[J]. 时珍国医国药, 2010, 21(1) |
| 作者姓名： | 江宇良 刘庆林 |
| 作者单位： | 厦门大学化学化工学院,福建,厦门,361005 |
| 基金项目： | 国家自然科学基金，教育部新世纪优秀人才计划项目，高等学校博士点专项基金 |
| 摘 要： | 目的 应用天然药用高分子材料海藻酸钠和淀粉制备复合微球并研究其对盐酸小檗碱的控制释放性能.方法 采用改进的乳化凝胶法制备复合微球,用光学显微镜观察了微球的形态,共聚焦激光扫描显微镜观察了药物的分布情况,紫外分光光度计测定了药物包封率,并测定了药物在不同介质中的释放.结果 微球形态圆整,分散性好,包封率可达到80%以上,对盐酸小檗碱具有一定的缓控释效果.结论 以海藻酸钠和淀粉为原料制备了性能良好的复合微球. |
| 关 键 词： | 海藻酸钠 淀粉 微球 盐酸小檗碱 |
Preparation of Alginate-starch Blend Microspheres for Controlled Release of Berberine Hydrochloride |
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| JIANG Yu-liang,LIU Qing-lin. Preparation of Alginate-starch Blend Microspheres for Controlled Release of Berberine Hydrochloride[J]. Lishizhen Medicine and Materia Medica Research, 2010, 21(1) | |
| Authors: | JIANG Yu-liang LIU Qing-lin |
| Affiliation: | JIANG Yu-liang,LIU Qing-lin(The College of Chemistry , Chemical Engineering,Xiamen University,Xiamen 361005,China) |
| Abstract: | Objective To prepare blend microspheres natural polymers alginate and starch and to study their controlled release performance on berberine hydrochloride.Methods A modified emulsification/gelation method was applied to prepare blend microspheres.Shape of those microspheres was observed with optical microscope.Drug distribution inside the Microspheres was observed with CLSM.Encapsulation efficiency was determined by UV-spectrophotometer.Drug release performance in two medium was also tested.Results Microsphe... |
| Keywords: | Alginate Starch Microsphere Berberine hydrochloride |
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