Selective recognition of malaria antigens by human serum antibodies is not genetically determined but demonstrates some features of clonal imprinting |
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| Authors: | Taylor, Rachel R. Egan, Andrea McGuinness, David Jepson, Annette Adair, Richard Drakely, Chris Riley, Eleanor |
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| Affiliation: | 1 Insttitute of Cell Animal and pupulation Biology, Division of Biological Sciences, Ashworth Laboratories, Univdersity of Edinbyrgh, West Mains Raod, Edinburgh 3jt, UK
2 Medical Research Council Laboratores PO Box 273, Fajara, The Gambia |
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| Abstract: | Malaria infection induces the production of serum antibodiesto a variety of malaria antigens but the prevalence of antibodiesto any particular antigen ins typically mucb less than 100%.It has been assumed that non-responsiveness to defined antigensin malaria immune subjects is due to HLA mediated restricutionof the Immune response. In this study we have investigated therole of HLA and non-HLA genes in the antibody response to twomerozoite surface antigens (MSP1 and MSP2) and a sexual stageantigen (Pfs260/230) opf P{lasmodium falcpartum, and concludethat host genotype is not a major determinant of responsiveness.Although antibody levels vary in accordance with seasonal variationsin malaria transmission in semi-immune children, antibiody levelsremain stable in clncall immine adults. |
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| Keywords: | antibodies clonal imprinting HLA malaria non-HLA genes |
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