某院重症医学科患者抗菌药物使用情况与多药耐药菌产生的相关性分析

目的:分析重症医学科(ICU)患者抗菌药物使用情况与多药耐药菌产生的相关性.方法:抽取医院2019年7月-2020年6月间ICU收治的重症患者113例临床资料,分析其抗菌药物使用情况(给药途径、用药频度、药物利用指数和联合用药),并采用Logistic回归法分析其使用情况与多药耐药菌产生的相关性.结果:113例重症患者...

Analysis on Correlation between Antimicrobials Medication and Production of Multi-drug Resistant Organisms in ICU Patients of a Hospital

Objective:To analyze the correlation between antimicrobials medication and production of multi-drug resistant organisms(MDRO)in ICU Patients of a Hospital.Methods:The clinical data of 113 critically illness patients admitted to ICU from July 2019 to June 2020 were extracted to analyze their antimicrobials medication(route of administration,drug frequency,drug utilization index and combined drug use),and the correlation between their usage and the generation of MDRO was analyzed using Logistic regression method.Results:Among 113 patients with severe disease,intravenous administration was the main route,and cefazolin had the highest drug frequency and drug utilization index.The combined utilization rate of more than 3 antibacterial drugs was higher than that of single drug and combined drug(P<0.05).The incidence of MDRO infection was 35.40%.The Logistic regression analysis showed that more than two drug types and long-term drug use were the influencing factors for the production of multi-drug resistant bacteria(OR>1,P<0.05).Conclusion:With the increase of the types of antibacterials combination and long-term drug use,there is a correlation between the drug combination and the production of MDRO,which is also an influencing factor for the production of MDRO.It is necessary to decrease the combined drug use and shorten the duration of drug use in order to delay the production of MDRO,which is beneficial to the rehabilitation of patients.