228例初治培阳肺结核病人短化疗效与耐药性分析

目的　分析228例初治培阳肺结核病人其耐药性与短化疗效的关系。方法 病人治疗采用全程隔日间歇短化方案，(2R₃H₃E₃Z₃/4R₃H₃)。采用绝对浓度法进行药敏测定。结果 33例初治耐药肺结核病例，经6个月正规短程化疗失败率高达12.1%。 (1)对耐R类药物者化疗失败率为40%(2/5)，敏感组化疗失败率为2.6% (5/195)，两组有显著性差异 (P＜0.05)；(2)对其他类 (不含耐R类)化疗失败率为7.1%，与敏感组比较无显著性差异 (P＞0.05)。二年随访耐药组细菌复发率为3.5%，敏感组细菌复发率为1.1%。结论 药物敏感病例和耐1种或2种药的病例 (不含耐R类)采用6个月短程化疗方案是合理有效的。

Analysis of the relationship between the drug-resistance and the short-course chemotherapy effect in 228 pulmonary tuberculosis patients

Objective To analyze the relationship between the drug resistance and the short course chemotherapy effect in 228 new smear positive pulmonary tuberculosis patients.Methods The treatment regimens of 228 cases were short course intermittent chemotherapy,and all cases had been done the susceptibility tests with absolute concentration method.Results After complete the 6 months treatment course,the rate of failure in 33 drug resistant cases was 12.1%. (1)In R resistant cases and drug sensitive cases,the rate of failure was respectively 40% (2/5) and 2.6%(5/195).There were significantly difference ( P< 0.05).(2)In the other drug resistant cases (except R resistant cases),the rate of failure was 7.1%,and it was no significantly difference from drug sensitive cases ( P >0.05).The check in 2 years showed that the positive conversion rate was 3.5% in drug resistant cases,and 1.1% in drug sensitive cases.Conclusion It is reasonable and effective to cure drug sensitive cases and drug resistant cases (except R) with the short course intermittent chemotherapy.