冠心病患者dTP比值分析及与预后的相关性

目的：分析冠心病患者血清11-脱氢-血栓素B2（11-dh-TXB2）与6-酮-前列腺素F1α（6-k-PGF1α）比值（dTP比值）的变化,评价冠心病患者dTP比值的影响因素及其与冠心病患者预后的关系。方法：203例住院患者应用酶联免疫法测定血浆中11-dh-TXB2和6-k-PGF1α水平,计算dTP比值。测定血液生化指标,记录心血管疾病危险因素、伴随临床疾病、超声心动图、冠状动脉造影结果。记录随访1年时主要不良心血管事件（MACE）。结果：冠心病患者dTP比值高于对照组。dTP比值与hs-CRP、TC水平及冠状动脉严重病变支数相关。临床合并高血压病、糖尿病的患者和介入治疗术后的患者dTP比值较高。患者住院时dTP比值增高与随访1年发生MACE相关。结论：冠心病患者dTP比值升高,不仅能够反映病情的严重性,而且预示患者1年内发生MACE的危险性增加。

Correlative study of dTP ratio and prognosis of coronary heart disease patients

Objective：To analyze the ratio of 11-dehydro-thromboxane B2 （11-dh-TXB2）and 6-keto-prostaglandin F1 alpha（6-keto-PGF1α（dTP ratio）in coronary heart disease（CHD）patients and evaluate correlated factors of dTP ratio and prognostic value of it.Methods：Two hundred and three consecutive hospitalized patients were enrolled.Euzymelinked immunosorbent assay was used to detect the serum levels of 11-dh-TXB2 and 6-keto-PGF1α then calculate dTP ratio.Recorded blood biochemical indicator,concomitant risk factors and diseases,ultrasonic echocardiogram,coronary arteriongraphy results and one-year follow-up major adverse cardiovascular events （MACE） were recorded.Results：The dTP ratio of CHD patients exceeded that of normal groups obviously.The dTP ratio correlated with the levels of hs-CRP,TC,the number of vessels diseased coronary artery,hypertension,diabetes and interventional therapy.Increased dTP ratio correlated with the risk of one-year follow-up MACE.Conclusion：Increased dTP ratio of CHD patients correlated with not only severe affection but also worse prognosis of one-year follow-up.