| 结直肠癌伴神经内分泌分化的研究进展 |
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| 引用本文： | 张海勇,姚根有. 结直肠癌伴神经内分泌分化的研究进展[J]. 国际病理科学与临床杂志, 2009, 29(6): 537-540 |
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| 作者姓名： | 张海勇 姚根有 |
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| 作者单位： | 浙江大学医学院病理学与法医学研究所,杭州,310058;浙江大学医学院病理学与法医学研究所,杭州,310058 |
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| 摘 要： | 结直肠癌伴神经内分泌分化是一种较为常见的现象。较多研究显示结直肠癌中神经内分泌细胞起源于内胚层的多潜能干细胞。结直肠癌的神经内分泌分化与IL-1, IL-6,转化生长因子β（transforming growth factor β, TGF-β）,B细胞淋巴瘤基因2（B-cell lymphoma gene 2, Bcl-2）,p53基因,N-myc下游调节基因1（N-myc downstream regulated gene 1,NDRG1）,再生基因4(regenerating gene Ⅳ, Reg Ⅳ)等有关。多数学者认为神经内分泌分化的出现预示着较差的预后,但近来很多研究显示神经内分泌分化的出现与预后无关。
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| 关 键 词： | 结直肠癌 神经内分泌细胞 分化 |
| 收稿时间： | 2009-11-25 |
| 修稿时间： | 2009-12-12 |
Progress in the study on colorectal cancer accompanied with neuroendocrine differentiation |
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| ZHANG Haiyong,YAO Genyou. Progress in the study on colorectal cancer accompanied with neuroendocrine differentiation[J]. Journal of International Pathology and Clinical Medicine, 2009, 29(6): 537-540 |
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| Authors: | ZHANG Haiyong YAO Genyou |
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| Affiliation: | Institute of Pathology and Forensic Medicine,Medical College,Zhejiang University,Hangzhou 310058,China |
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| Abstract: | Colorectal cancer accompanied with neuroendocrine differentiation is a morecommon phenomenon. It has been reported that neuroendocrine cells in colorectal canceroriginate from the multi-potential stem cells in endoderm. The differentiation ofneuroendocrine in colorectal cancer is closely relates with IL-1, IL-6, transforminggrowth factor β (TGF-β), B-cell lymphoma gene 2 (Bcl-2), p53 gene, N-myc downstreamregulated gene 1 (NDRG1 ), regenerating gene Ⅳ (Reg Ⅳ) and so on. It is well recognizedthat the emergence of neuroendocrine differentiation indicates the poor prognosis,However, many recent studies suggest that the emergence of neuroendocrine differentiationhas nothing to do with the prognosis. |
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| Keywords: | colorectal cancer neuroendocrine cell differentiation |
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