| SDF-1/CXCR4与眼部新生血管性疾病的研究进展 |
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| 引用本文： | 黄礼彬,韩晓丽,徐国兴. SDF-1/CXCR4与眼部新生血管性疾病的研究进展[J]. 国际眼科杂志, 2008, 8(4): 791-793 |
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| 作者姓名： | 黄礼彬 韩晓丽 徐国兴 |
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| 作者单位： | 福建医科大学附属第一医院眼科,中国福建省福州市,350005 |
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| 摘 要： | 基质细胞衍生因子-1(stromal cell derived factor 1,SDF-1)是α组趋化因子家族的一个新成员,最早从骨髓的基质细胞中分离出来,其特异性受体CXCR4广泛地表达在许多组织和器官上,SDF-1/CXCR4在调节免疫和炎症反应、调控造血、恶性肿瘤细胞的浸润转移、血管生成等方面发挥着重要的作用。本文从SDF-1/CXCR4的结构、功能、形成新生血管的机制及其与眼部新生血管性疾病的关系等方面进行综述。
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| 关 键 词： | 基质细胞衍生因子-1 SDF-1/CXCR4 新生血管 |
| 修稿时间： | 2007-12-08 |
Research advances of SDF-1/CXCR4 and angiogenesis disease in eyes |
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| Li-Bin Huang,Xiao-Li Han,Guo-Xing Xu. Research advances of SDF-1/CXCR4 and angiogenesis disease in eyes[J]. International Eye Science, 2008, 8(4): 791-793 |
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| Authors: | Li-Bin Huang Xiao-Li Han Guo-Xing Xu |
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| Affiliation: | Department of Ophthalmology,the First Affliated Hospital of Fujian Medical University,Fuzhou 350005,Fujian Province,China |
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| Abstract: | Stromal cell derived factor 1(SDF-1)is a new member of α group chemokine,and it was first isolated from bone marrow stroma cells.Specific SDF-1 receptor,CXC chemokine receptor 4(CXCR4),plays very important roles in inducing immune and inflammatory reaction,modulability of hemopoiesis,invasion and metastasis of malignant tumors and angiogenesis.The review article focuses on the structure,function and mechanism of angiogenesis,especially the relationship between SDF-1/CXCR4 and angiogenesis disease in eyes. |
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| Keywords: | stromal cell derived factor 1 SDF-1/CXCR4 angiogenesis |
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