Association Between Sleep Problems and Perceived Cognitive Dysfunction Over 12 Months in Individuals with Multiple Sclerosis |
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| Authors: | Abbey J Hughes Aaron P Turner Kevin N Alschuler David C Atkins Meghan Beier Dagmar Amtmann |
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| Institution: | 1. Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA;2. MS Center of Excellence–West, VA Puget Sound Health Care System, Seattle, Washington, USA;3. MS Center of Excellence–West, VA Puget Sound Health Care System, Seattle, Washington, USA;4. Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA;5. Department of Neurology, University of Washington, Seattle, Washington, USA;6. Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA;7. Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, Maryland, USA |
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| Abstract: | Sleep problems are highly prevalent among individuals with multiple sclerosis (MS); however, the relationship between sleep problems and cognitive dysfunction is poorly understood in this population. In the present study, 163 individuals with MS and depression, fatigue, or pain completed self-report measures of sleep, cognitive dysfunction, and relevant demographic and clinical characteristics (e.g., disability severity, depressive symptomatology, pain intensity, fatigue impact) at four time points over 12 months. Mixed-effects regression demonstrated that poorer sleep was independently associated with worse perceived cognitive dysfunction (β = –0.05, p = .001), beyond the influence of depressive symptomatology. Fatigue impact was found to partially mediate this relationship. Results suggest that for individuals with MS and depression, fatigue, or pain, self-reported sleep problems are related to perceived cognitive dysfunction, and that fatigue impact accounts for part of this relationship. |
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