Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia

Authors:	Lau Lai-Ching Lim Ping Lim Yik-Chen Teng Li-Min Lim Tse-Hui Lim Lay-Cheng Tan Soo-Yong Lim Soon-Tiong Sanger Warren G Tien Sim-Leng

Affiliation:	^aDepartment of Pathology, Singapore General Hospital, Outram Road, Singapore 169608;^bDepartment of Hematology, Singapore General Hospital, Singapore;^cHuman Genetics Laboratory, University of Nebraska Medical Center, Omaha, NE 68198

Abstract:	Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association with follicular lymphoma and the t(8;14) is associated with T-cell neoplasia. Occurrence of these three abnormalities in CLL are rare, and the significance of this finding is unclear. Further studies of similar cases may shed additional insight into this finding.

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