| Y 染色体微缺失与男性不育的关系探讨 |
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| 引用本文： | 赵江霞,李红钢,张宇. Y 染色体微缺失与男性不育的关系探讨[J]. 武汉大学学报(医学版), 2006, 27(6): 794-796 |
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| 作者姓名： | 赵江霞 李红钢 张宇 |
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| 作者单位： | 武汉市第七医院病理科,武汉,430071;华中科技大学同济医学院生殖医学中心,武汉,430030;同济大学生命科学院生物技术专业2004级,上海,200039 |
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| 摘 要： | 目的:探讨不育男性无精子症或严重少精子症与Y染色体微缺失之间的关系。方法:利用15个Y染色体特异序列标签位点,以多重PCR法检测无精子症或严重少精子症患者的Y染色体微缺失情况。结果:31例无精子症或严重少精子症患者中共检出Y染色体微缺失3例,缺失率为9.7%。结论:Y染色体微缺失是造成男性精子发生障碍的常见病因之一。
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| 关 键 词： | 男性不育 Y染色体微缺失 无精子症 严重少精子症 |
| 文章编号： | 1671-8852(2006)06-0794-03 |
| 收稿时间： | 2006-05-25 |
| 修稿时间： | 2006-05-25 |
A Research on Relation Between Y Chromosome Microdeletions and Male Infertility |
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| ZHAO Jiangxia,LI Honggang,ZHANG Yu. A Research on Relation Between Y Chromosome Microdeletions and Male Infertility[J]. Medical Journal of Wuhan University, 2006, 27(6): 794-796 |
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| Authors: | ZHAO Jiangxia LI Honggang ZHANG Yu |
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| Affiliation: | 1.Dept. of Pathology, the Seventh Hospital of Wuhan, Wuhan 430071, China; 2.Reproductive Medical Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 3.Life Science College, Tongji University, Shanghai 200039, China |
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| Abstract: | Objective: To assess the relationship between azoospermia or severe oligozoospermia and Y chromosomal microdeletions.Methods: Infertile men with azoopermia or severe oligozoospermia were screened by multi-polymerase chain reactions with 15 Y chromosome specificsequence-tagged site labels.Results: Microdeletions were detected in 9.7%(3/31) infertile men with azoospermia or severe oligozoospermia.Conclusion: Y chromosome microdeletion is one of the causes which result in male spermatogenetic obstacle. |
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| Keywords: | Male Infertility Y Chromosomal Microdeletions Azoospermia Severe Oligozoospermia |
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