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血管活性肠肽对大鼠贮脂细胞Ⅰ型胶原分泌的影响
引用本文:陈原稼,尹珊珊,马雷梅,王宝恩,陈元方. 血管活性肠肽对大鼠贮脂细胞Ⅰ型胶原分泌的影响[J]. 中华肝脏病杂志, 1995, 0(3)
作者姓名:陈原稼  尹珊珊  马雷梅  王宝恩  陈元方
作者单位:北京协和医院,北京友谊医院
摘    要:
我们研究发现在传代培养的大鼠贮脂细胞中,不同浓度的血管活性肠肽(Vasoacfiveinfesfinalpeptide,VIP)能显著抑制Ⅰ型胶原分泌并呈量效关系。VIP受体拮抗剂能减弱VIP这一作用,从而更加肯定VIP抑制胶原分泌的作用。本研究提示:大鼠贮脂细胞膜上存在VIP受体;VIP在肝纤维化和肝硬化时浓度升高可能调节肝脏胶原代谢。

关 键 词:胶原,血管活性肠肽,肝纤维化,贮脂细胞,受体

THE EFFECT OF VASOACTIVE INTESTINAL PEPTIDE ON SECRETION OF COLLAGEN TYPE I BY RAT LIPOCYTES
Yuan-jia Chen,Shan-shan Ying,Yuan-fang Chen,Deparment of Gas-troenterology,Peking Union Medical Collge Hospital .Peking Union Medical College,Beijing. THE EFFECT OF VASOACTIVE INTESTINAL PEPTIDE ON SECRETION OF COLLAGEN TYPE I BY RAT LIPOCYTES[J]. Chinese journal of hepatology, 1995, 0(3)
Authors:Yuan-jia Chen  Shan-shan Ying  Yuan-fang Chen  Deparment of Gas-troenterology  Peking Union Medical Collge Hospital .Peking Union Medical College  Beijing
Affiliation:Yuan-jia Chen,Shan-shan Ying,Yuan-fang Chen,Deparment of Gas-troenterology,Peking Union Medical Collge Hospital .Peking Union Medical College,Beijing,10073
Abstract:
Lipocytes(Ito cells)are primary cellular source of hepatic collagen. Some reports demonstrated that high plasma levels of vasoactive intestinal peptide(VIP)was detected in patients with cirrhosis or in animal models of cirrhosis.To investigate whether VIP involving in secretion of collagen by lipocytes or not,we observed that the effects of VIP at various concentrations on the secretion of collagen type I by rat Ito cells in vitro. The data showed that VIP obviously inhibited the secretion of collagen in a dose-dependent manner(r=0.989,n=6,P<0.001).VIP receptor antagonist declined the inhibitory action of VIP on secretion of collagen.These results suggest that:the existence of VIP receptors on plasma membrance of rat lipocytes ;VIP may regulate the metabolism of collagen in liver fibrosis or cirrhosis by its high plasma level.
Keywords:Collagen Vasoactive intestinal peptide Liver fibrosis Lipocyte Receptor  
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