Matrix metalloproteinase-1 expression inhibitory compound from the whole plants of Viola ibukiana Makino |
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| Authors: | Moon Hyung-In Kim Mi-Ran Cho Moon Kyun Park Soojie Chung Jin-Ho |
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| Institution: | Department of Dermatology, Seoul National University College of Medicine and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Seoul, 110-744, Korea. |
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| Abstract: | Bioassay-guided fractionation has led to the isolation of two triterpenoid saponins 3-O-O-beta-D-glucopyranosyl-(1 --> 3)-O-beta-D-glucopyranosyl] oleanolic acid (1), and 3-O-O-beta-D-glucopyranosyl-(1 --> 2)-O-beta-D-glucopyranosyl] oleanolic acid (2) from the whole plants of Viola ibukiana Makino. Compound 2 showed matrix metalloproteinase-1 expression inhibition activities in a dose-dependent manner. |
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| Keywords: | Viola ibukiana Makino Violaceae triterpenoid saponins matrix metalloproteinase‐1 inhibitor |
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