| BCEF0083对慢性应激抑郁模型大鼠海马神经元及脑源性神经营养因子mRNA表达的影响研究 |
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| 引用本文： | 程燕,明亮,周兰兰,江琴. BCEF0083对慢性应激抑郁模型大鼠海马神经元及脑源性神经营养因子mRNA表达的影响研究[J]. 中国药房, 2006, 17(10): 738-740 |
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| 作者姓名： | 程燕 明亮 周兰兰 江琴 |
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| 作者单位： | 安徽医科大学药理教研室,合肥市,230032 |
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| 摘 要： | 目的:研究BCEF0083对慢性应激抑郁模型大鼠海马神经元及脑源性神经营养因子(BDNF)mRNA表达的影响。方法:将大鼠随机分为对照组、模型组、吗氯贝胺20mg/kg组以及BCEF0083100、50、25mg/kg组,用HE染色法观察海马神经元数目的变化,用逆转录-聚合酶链反应法检测海马BDNFmRNA的表达。结果:BCEF0083可增加慢性应激抑郁模型大鼠海马神经元数目及上调BDNFmRNA的表达。结论:BCEF0083的抗抑郁作用可能与增加慢性应激抑郁模型大鼠海马神经元数目及上调BDNFmRNA的表达有关。
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| 关 键 词： | 慢性应激 抑郁模型 大鼠 海马 神经元 脑源性神经营养因子 |
| 文章编号： | 1001-0408（2006）10-0738-03 |
| 收稿时间： | 2005-11-08 |
| 修稿时间： | 2006-02-21 |
Effects of BCEF on Hippocampus Neurons and mRNA Expression of BDNF in Chronic Stress Depression Rat Models BCEF |
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| CHENG Yan,MING Liang,ZHOU Lanlan,JIANG Qin. Effects of BCEF on Hippocampus Neurons and mRNA Expression of BDNF in Chronic Stress Depression Rat Models BCEF[J]. China Pharmacy, 2006, 17(10): 738-740 |
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| Authors: | CHENG Yan MING Liang ZHOU Lanlan JIANG Qin |
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| Affiliation: | Dept. of Pharmacology, Anhui Medical University, Hefei 230032, China |
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| Abstract: | OBJECTIVE:To explore the effects of bioactive compounds from entomogenous fungi(BCEF0083)on hip-pocampus neurons and mRNA expression of BDNF in chronic stress depression rat models.METHODS:The selected rats were randomly divided into control group,model group,moclobemide20mg/kg group,and BCEF0083100,50,25mg/kg groups.The change in hippocampus neuron numbers were observed by HE staining and mRNA expression of BDNF was detected with RT-PCR.RESULTS:BCEF0083could increase the neuron numbers and up-regulate the expression of BDNF mRNA in hippocampus.CONCLUSION:The antidepressant effect of BCEF0083in chronic stress depression rat models is probably re-lated to the increase in hippocampus neuron numbers and up-regulation of expression of BDNF mRNA in hippocampus. |
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| Keywords: | Chronic stress Depression model Rat Hippocampus Neuron BDNF |
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