| 活心方对冠心病心绞痛患者临床疗效及血清VEGF水平的影响 |
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| 引用本文： | 张超,姚成增,蒋梅先,胡琪祥,关敬树,曹飞. 活心方对冠心病心绞痛患者临床疗效及血清VEGF水平的影响[J]. 中国实验方剂学杂志, 2014, 20(16): 180-183 |
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| 作者姓名： | 张超 姚成增 蒋梅先 胡琪祥 关敬树 曹飞 |
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| 作者单位： | 宝山区中西医结合医院心内科, 上海 201900;上海中医药大学附属曙光医院心内科, 上海 200021;上海中医药大学附属曙光医院心内科, 上海 200021;上海中医药大学附属曙光医院心内科, 上海 200021;宝山区中西医结合医院心内科, 上海 201900;上海市普陀区人民医院中医科, 上海 200060 |
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| 基金项目： | 上海市卫生局基金项目（ZYSNXD-CC-HPGC-JD-003）；上海市科委基金项目（05dz19506）；上海市卫生系统优秀青年人才培养计划项目（XYQ2011064） |
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| 摘 要： | 目的:观察中药活心方加载治疗对冠心病心绞痛患者的临床疗效及血清血管内皮生长因子(VEGF)水平的影响。方法:将60例冠心病心绞痛患者随机分为两组,中药加载组(n=31)和对照组(n=29);对照组采用西药常规治疗,中药加载组在西药常规治疗的基础上给予活心方加载治疗。对两组患者的中医证候疗效、心绞痛疗效、左室射血分数(LVEF)及血清VEGF水平进行观测。结果:经治疗后,与对照组相比,中药加载组患者的中医证候积分进一步降低(P<0.05),中医证候疗效和心绞痛疗效总有效率更高(P<0.05);与治疗前相比,中药加载组患者治疗后LVEF及血清VEGF水平得以提高(P<0.05,P<0.01),而对照组无显著性变化,治疗后组间有显著差异(P<0.05)。结论:活心方加载治疗可进一步改善冠心病心绞痛患者的临床症状,提高临床疗效,并增加患者LVEF和提高其血清VEGF水平。
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| 关 键 词： | 活心方 冠心病心绞痛 临床疗效 血管内皮生长因子 |
| 收稿时间： | 2014-04-18 |
Effects of Huoxin Prescription on Therapeutic Efficacy of Angina Pectoris of Coronary Heart Disease and Serum Level of VEGF |
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| ZHANG Chao,YAO Cheng-zeng,JIANG Mei-xian,HU Qi-xiang,GUAN Jing-shu and CAO Fei. Effects of Huoxin Prescription on Therapeutic Efficacy of Angina Pectoris of Coronary Heart Disease and Serum Level of VEGF[J]. China Journal of Experimental Traditional Medical Formulae, 2014, 20(16): 180-183 |
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| Authors: | ZHANG Chao YAO Cheng-zeng JIANG Mei-xian HU Qi-xiang GUAN Jing-shu CAO Fei |
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| Affiliation: | Dept. of Cardiology of Baoshan Integrated Traditional and Western Medicine Hospital, Shanghai 201900, China;Dept. of Cardiology of Shuguang Hospital Affiliated Shanghai University of Traditional Chinese Medicine(TCM), Shanghai 200021, China;Dept. of Cardiology of Shuguang Hospital Affiliated Shanghai University of Traditional Chinese Medicine(TCM), Shanghai 200021, China;Dept. of Cardiology of Shuguang Hospital Affiliated Shanghai University of Traditional Chinese Medicine(TCM), Shanghai 200021, China;Dept. of Cardiology of Baoshan Integrated Traditional and Western Medicine Hospital, Shanghai 201900, China;Dept. of TCM of Putuo People's Hospital, Shanghai 200060, China |
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