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Restriction endonuclease analysis of varicella-zoster vaccine virus and wild-type DNAs |
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| Authors: | J H Martin D E Dohner W J Wellinghoff L D Gelb |
| Abstract: | The DNA from several clinical isolates of varicella-zoster virus (VZV) were compared with the DNA from the vaccine strain VZV using three restriction endonucleases: BamHI, BgII, and HpaI. When electrophoresed through an agarose gel, the vaccine DNA digestion pattern was significantly different from the digestion patterns of the wild-type DNAs. Variations in the digestion pattern of the separate clinical isolates were also observed. |
| Keywords: | varicella-zoster vaccine DNA endonuclease analysis viral strain subtyping |