| 紫外分光光度法测定阿替洛尔缓释微囊含量 |
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| 引用本文： | 赛那,金蓉,顾艳丽,贾颖.紫外分光光度法测定阿替洛尔缓释微囊含量[J].北方药学,2015(1):19-20. |
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| 作者姓名： | 赛那 金蓉 顾艳丽 贾颖 |
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| 作者单位： | 1. 内蒙古医科大学药学院 呼和浩特 010110;2. 内蒙古医科大学基础医学院 呼和浩特 010110 |
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| 摘 要： | 目的：建立以紫外分光光度法测定阿替洛尔缓释微囊含量的方法。方法：将阿替洛尔缓释微囊研磨破碎，转移至容量瓶中，稀释后，在224nm处进行含量测定。结果：阿替洛尔在224nm处有最大吸收，辅料对测定无干扰。标准曲线方程：A=0.0355C+0.0014，线性范围为2.5～20.0μg·ml-1。回收率98.81%～99.36%，精密度和稳定性RSD均在2%以内，符合《中国药典》的要求。
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| 关 键 词： | 紫外分光光度法 阿替洛尔缓释微囊 含量测定 |
Determination of atenolol sustained-release microcapsules content by UV Spectrophotometry |
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| Sai Na
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Jin Rong
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Gu YanLi
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Jia Ying.Determination of atenolol sustained-release microcapsules content by UV Spectrophotometry[J].BEIFANG YAOXUE,2015(1):19-20. |
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| Authors: | Sai Na Jin Rong Gu YanLi Jia Ying |
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| Abstract: | Objective: to establish a method for determination of atenolol sustained-release microcapsules content by ultraviolet spectrophotometry. Methods:to grind the atenolol sustained-release microcapsules, transferred to a volumetric flask, determining content at 224nm. Results: the atenolol has maximum absorption at 224nm, excipients do not interfere with the determination. standard curve equation: A=0.0355C+0.0014, linear range is 2.5~20.0μg·ml-1. The rate of recovery is 98.81%~99.36%, the precision and stability of RSD are within 2%. |
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| Keywords: | UV spectrophotometry Atenolol sustained-release microcapsules Determination of content |
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