喹硫平与舒必利改善精神分裂症患者认知功能的比较研究

目的：观察喹硫平与舒必利对精神分裂症患者认知功能的改善情况。方法：将50例初诊或经典抗精神病药物治疗疗效不显著或无法耐受不良反应的精神分裂症患者分为喹硫平（n=25）与舒必利（n=25）两组，进行为期3个月的治疗。治疗前后应用PANSS、MMES分别评定精神症状与认知功能。结果：共39例患者完成3个月的治疗（喹硫平=19，舒必利=20）。与基线比较，喹硫平与舒必利都能明显改善精神分裂症患者的精神症状与认知功能，但两组间精神症状与认知功能改善程度并无差异。结论：喹硫平与舒必利都能明显改善精神分裂症患者的认知障碍，疗效无差异。

Comparison of quetiapine and sulpiride on cognitive function in patients with schizophrenia

Objietive: The objective of this study is to compare effects of quetiapine and sulpiride on cognitive function in patients with schizophrenia. Methods: Fifty patients with schizophrenia, who were newly diagnosed or had either failed to demonstrate sufficient clinical improvement or to tolerate adverse drug effects, were assigned to quetiapine or sulpiride treatment. The psychotic symptoms and cognitive functions were assessed by PANSS or MMES tests, respectively. Results: Thirty-nine patients completed the three-month treatment. Compared with baseline,the psychotic symptoms and cognitive functions were markedly improved after treatments. However, no significant difference was observed between quetiapine and sulpiride treatments. Conclusions: Quetiapine and sulpiride improved equivalently cognitive functions in patients with schizophrenia.