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| GSTP1、XRCC1基因多态性与结直肠癌个体化治疗的研究进展 | |
| 引用本文： | 吴云云,刘鹏飞. GSTP1、XRCC1基因多态性与结直肠癌个体化治疗的研究进展[J]. 医学综述, 2014, 20(18): 3319-3321 |
| 作者姓名： | 吴云云 刘鹏飞 |
| 作者单位： | 1. 苏州大学附属第一医院普外科,江苏苏州,215006 2. 南通大学附属吴江第一人民医院胃肠外科,江苏吴江,215200 |
| 摘 要： | 近年来,根据肿瘤个体基因特征进行个体化治疗正日益成为国内外学者关注的焦点。对结直肠癌患者进行药物基因组学研究发现,谷胱甘肽转移酶P1(GSTP1)、X线修复交叉互补基因1(XRCC1)、二氢嘧啶脱氢酶基因、甲基四氢叶酸还原酶等基因的多态性可能会影响化疗效果、生存时间和不良反应,可为实施个体化治疗提供了新的预测指标。该文着眼于国内外学者对GSTP1和XRCC1基因多态性的检测和分析,对其研究进展予以综述。 |
| 关 键 词： | 谷胱甘肽转移酶P1 X线修复交叉互补基因 多态性 药物基因组学 结直肠癌 个体化治疗 |
GSTP1,XRCC1 Polymorphisms and the Individualized Treatment of Colorectal Cancer |
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| WU Yun-yun,LIU Peng-fei. GSTP1,XRCC1 Polymorphisms and the Individualized Treatment of Colorectal Cancer[J]. Medical Recapitulate, 2014, 20(18): 3319-3321 | |
| Authors: | WU Yun-yun LIU Peng-fei |
| Affiliation: | WU Yun-yun(Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China) LIU Peng-fei(Wujiang City First People＇s Hospital Affiliated to Nantong University, Wujiang 215200, China) |
| Abstract: | In recent yems,individualized treatment according to the characters of tumor individual genes is increasingly becoming the focus of scholars at home and abroad.The study of chemotherapy in colorectal cancer found that the gene polymorphism loci in GSTP1,XRCC1,DPYD,MTHFR may affect the chemotherapy effect,the survival time and adverse reactions,providing a new predictor for the implementation of individualized treatment.Here is to make a review of the research progress in detection and analysis of GSTP1 and XRCC1 polymorphisms. |
| Keywords: | GSTP1 XRCC1 Gene polymorphisms Pharmacogenomics Colorectal cancer Individualized treatment |
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