妊娠高血压综合征患者循环内皮祖细胞功能的研究

目的研究妊娠高血压综合征患者循环内皮祖细胞功能的变化。方法选择2010年10月～2011年8月于我院产科住院的妊娠高血压综合征患者12例作为研究对象（妊娠高血压综合征组），同时选取12例正常妊娠的同期入院患者作为对照组。分离两组患者外周血单个核细胞进行体外诱导培养以获得内皮祖细胞，并对其增殖、黏附、迁移能力进行检测。结果各组骨髓单个核细胞在体外培养下均能够获得内皮祖细胞．与对照组比较，妊娠高血压综合征组内皮祖细胞增殖、黏附、迁移能力均有不同程度的下降。结论妊娠高血压综合征的发生与循环内皮祖细胞功能的下调存在明显的相关性。

Study on the function of circulating endothelial progenitor cell in the patients with pregnancy induced hypertension syndrome

Objective To study the changes of circulating endothelial progenitor cell＇s function in the patients with pregnancy induced hypertension syndrome. Methods 12 patients suffered from pregnancy induced hypertension syndrome hospitalized in the department of obstetrics of our hospital from October 2010 to August 2011 were selected as study objects （pregnancy induced hypertension syndrome group）, 12 hospitalized normal pregnant women at the corresponding time period were selected as control group. The peripheral blood mononuelear cells were separated and cultured in vitro to obtain endothelial progenitor cells in each group. The abilities of endothelial progenitor cell＇s proliferation, adhesion, migration were assessed. Results Endothelial progenitor cells could be attained from peripheral blood mononuclear cells when cultured in vitro in each group. The abilities of endothelial progenitor cell＇s proliferation, adhesion, migration in the pregnancy induced hypertension syndrome group were down-regulation compared with the control group. Conclusion The occurrence of pregnancy induced hypertension syndrome is associated with the down-regulation of circulating endothelial progenitor cell＇s function evidently.