| nm23-H1基因表达与鼻咽癌的早发转移 |
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| 引用本文： | 赖振南,黄应桂,余忠华.nm23-H1基因表达与鼻咽癌的早发转移[J].肿瘤研究与临床,2005,17(3):173-174. |
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| 作者姓名： | 赖振南 黄应桂 余忠华 |
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| 作者单位： | 1. 524001,湛江,广东医学院附属医院放疗科
2. 524001,湛江,广东医学院附属医院病理科 |
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| 摘 要： | 目的探讨nm23-H1基因产物的表达与鼻咽癌早发转移的关系.方法应用免疫组化S-P法对95例鼻咽癌组织蜡块进行nm23-H1检测.结果nm23-H1的阳性表达率为47.4%(45/95),早发转移组nm23-H1阳性率(26.7%)低于无转移组(60.0%),差异有统计学意义(P＜0.05).nm23-H1表达与临床分期无关.结论nm23-H1阴性表达与鼻咽癌早发转移有关,nm23-H1的表达水平可能是预测中晚期鼻咽癌远处转移的一个重要的生物学指标.
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| 关 键 词： | nm23-H1 基因 鼻咽肿瘤 远处转移 |
| 文章编号： | 1006-9801(2005)03-0173-02 |
| 修稿时间： | 2004年12月14 |
Relationship between the expression of nm23-H1 gene and early distant metastases in nasopharyngeal carcinoma |
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| LAI Zhen-nan,HUANG Ying-gui,YU Zhong-hua.Relationship between the expression of nm23-H1 gene and early distant metastases in nasopharyngeal carcinoma[J].Cancer Research and Clinic,2005,17(3):173-174. |
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| Authors: | LAI Zhen-nan HUANG Ying-gui YU Zhong-hua |
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| Abstract: | Objective To study the relationship between the expression of nm23- H1 gene product and early distant metastases in nasopharyngeal carcinoma (NPC). Methods The S- P immunohistochemical method was used to detect the expression of nm23- H1 in 95 cases of NPC. Results The positive rate of nm23- H1 was 47.4 % (45/95). The positive rate of nm23- H1 in early distant metastases group (26.7 %) was much lower than those without distant metastases group (60.0 %) (P <0.05). The expression of nm23- H1 has no relation with clinical stage. Conclusions The negative expression of nm23- H1 was relative to the early distant metastases. The expression levels of nm23- H1 gene may be an important biological indicator for predicting distant metastases in middle to advanced NPC. |
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| Keywords: | nm23-H_1 gene Nasopharyngeal carcinoma Distant metastases |
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