血小板反应蛋白和内皮抑素在皮肤血管瘤不同时期的表达

目的探讨血小板反应蛋白(thrombospondin1)和内皮抑制素(endostatin)在血管瘤发生、发展及退化过程中的表达状况及其意义。方法采用S P免疫组织化学方法检测人皮肤血管瘤增生期、退化期及正常皮肤组织及内皮中血小板反应蛋白和内皮抑素的表达水平。利用计算机图像分析技术测量不同时期血管瘤组织和正常组织中血小板反应蛋白和内皮抑素表达的平均吸光度和平均阳性面积。结果退化期血管瘤中血小板反应蛋白和内皮抑素表达高于增生期,差异有统计学性意义(P<0.01),增生期血管瘤中血小板反应蛋白和内皮抑素表达高于正常组织,差异有统计学意义(P<0.01)。结论血小板反应蛋白和内皮抑素可能通过抑制血管生成而促进血管瘤的消退。

Expression of thrombospondin-1 and endostatin at different stage of human dermal hemangiomas

Objective To investigate the expression and significance of thrombospondin-1 and endostatin in the occurrence, development and regression of human hemangiomas. Methods We examined the expression and significance of thrombospondin-1 and endostatin in the occurrence, development and regression of human hemangiomas and normal skin tissues using immunohistochemical technique. An image analysis system was used to measure the average optical density and the rate of positive area of thrombospondin-1 and endostatin in different stages of hemangiomas and in normal skin tissues. Results The expression of thrombospondin-1 and endostatin was significantly higher in degenerating hemangiomas than in proliferating one (P<0.01), and there was difference between proliferating hemangiomas and normal skin tissues (P<0.01). Conclusion Thrombospondin-1 and endostatin may promote hemangioma degeneration by anti-angiogenesis.