Vanadium exposure-induced neurobehavioral alterations among Chinese workers |
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| Institution: | 1. Department of Occupational Health, West China School of Public Health Sichuan University, Chengdu, Sichuan, PR China;2. Institute of Occupational Health Prevention, Panzhihua Iron and Steel Vanadium and Titanium Co., Ltd., Panzhihua, Sichuan, PR China;3. School of Health Sciences, Purdue University, West Lafayette, IN, USA;1. Swiss Center for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, Pharmacenter, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland;2. Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), Computer Aided Molecular Design Group, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria;1. Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA;2. College of Arts and Sciences, Lynn University, 3601 North Military Trail, Boca Raton, FL 33431, USA;1. Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, United States;2. Toxicology Excellence for Risk Assessment, Cincinnati, OH, United States;3. Toxicology Consulting Services, Bonita Springs, FL, United States;4. Exponent, Midland, MI, United States;1. State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China;2. Center for Environmental Health Research, South China Institute of Environmental Sciences, MEP, Guangzhou 510535, China;3. State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China;4. Institute of Environmental Health and Related Product Safety, China CDC, Beijing 100021, China;5. State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China;1. Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland;2. University of Warsaw, Faculty of Chemistry, Biological and Chemical Research Centre, Warsaw, Poland |
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| Abstract: | Vanadium-containing products are manufactured and widely used in the modern industry. Yet the neurobehavioral toxicity due to occupational exposure to vanadium remained elusive. This cross-sectional study was designed to examine the neurotoxic effects of occupational vanadium exposure. A total of 463 vanadium-exposed workers (exposed group) and 251 non-exposed workers (control group) were recruited from a Steel and Iron Group in Sichuan, China. A WHO-recommended neurobehavioral core test battery (NCTB) and event-related auditory evoked potentials test (P300) were used to assess the neurobehavioral functions of all study subjects. A general linear model was used to compare outcome scores between the two groups while controlling for possible confounders. The exposed group showed a statistically significant neurobehavioral alteration more than the control group in the NCTB tests. The exposed workers also exhibited an increased anger-hostility, depression-dejection and fatigue-inertia on the profile of mood states (p < 0.05). Performances in the simple reaction time, digit span, benton visual retention and pursuit aiming were also poorer among exposed workers as compared to unexposed control workers (p < 0.05). Some of these poor performances in tests were also significantly related to workers’ exposure duration. P300 latencies were longer in the exposed group than in the control (p < 0.05). Longer mean reaction times and more counting errors were also found in the exposed workers (p < 0.05). Given the findings of our study and the limitations of neurobehavioral workplace testing, we found evidence of altered neurobehavioral outcomes by occupational exposure to vanadium. |
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