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A Significant Correlation between Nuclear CXCR4 Expression and Axillary Lymph Node Metastasis in Hormonal Receptor Negative Breast Cancer
Authors:Sang Uk Woo  Jeoung Won Bae  Chul Hwan Kim  Jae Bok Lee  Byum Whan Koo
Affiliation:(1) Department of Pathology, Korea University College of Medicine, #126-1 Anam Dong 5 Ga, Sung Buck Gu, Seoul, Republic of Korea;(2) Department of Surgery, Korea University College of Medicine, #126-1 Anam Dong 5 Ga, Sung Buck Gu, Seoul, 136-705, Republic of Korea
Abstract:Background and objectives In breast cancer, the expression pattern of CXCR4 may be correlated with the degree of axillary lymph node involvement. The aim of this study was to evaluate the contributing factors that contribute to the correlation between CXCR4 expression and axillary lymph node metastasis in breast cancer. Methods Between August 1997 and August 2002, sections of paraffin-embedded tissue were obtained from 107 patients who received optimal treatment for breast cancer. The expression of CXCR4 was evaluated by immunohistochemical staining. Results A significant correlation was found in the expression of nuclear CXCR4 and lymph node metastasis (P = 0.03). We found a significant correlation between a high nuclear expression of CXCR4 and axillary lymphatic metastasis in estrogen and progesterone receptor negative breast cancer (P = 0.01 and P = 0.01). There was a significant correlation between the high expression of nuclear CXCR4 and axillary lymphatic metastasis in comparisons between positive estrogen and/or progesterone receptor expression and negative expression (P = 0.02). Conclusions Our results showed that high expression of nuclear CXCR4 was significantly correlated with lymph node metastasis in breast cancer. The high expression of nuclear CXCR4 in hormone receptor negative breast cancer was associated with a high possibility of lymph node metastasis.
Keywords:Breast cancer  Lymph node metastasis  CXCR4  Estrogen receptor  Progesterone receptor
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