阿替普酶联合丁苯酞改善脑梗死患者脑血管储备功能及血流动力学的作用研究

目的 研究阿替普酶联合丁苯酞改善脑梗死患者脑血管储备功能及血流动力学的作用.方法 选取2019年5月～2021年5月烟台市莱阳中心医院收治的108例脑梗死患者作为研究对象,全体患者入院后均采取控制血脂、血压、神经营养、清除自由基等常规治疗方法,根据随机数表法进行分组,每组54例.参照组患者在常规治疗基础上运用阿替普酶药...

Effect of Alteplase Combined with Butylphthalide on Cerebrovascular Reserve Function and Hemodynamics in Patients with Cerebral Infarction

Objective To study the effect of alteplase combined with butylphthalide on cerebral vascular reserve function and hemodynamics in patients with cerebral infarction.Methods 108 patients with cerebral infarction admitted to Laiyang Central Hospital from May 2019 to May 2021 were selected as the study objects.After admission,all patients were divided into groups according to random number table method.Both groups were given routine treatments,such as blood lipid,blood pressure control,neuronutrition,free radical elimination,etc.Each group included 54 cases.In the control group,the patients were treated with antithrombotic regimen of alteplase and the patients in the study group were treated with antithrombotic regimen of alteplase combined with butylphthalide.The purpose of this study was to investigate the cerebral vascular reserve function and the role of hemodynamics.Results After treatments,the indexes of cerebrovascular reserve function in the study group were higher than those in the control group,and the indexes of mean cerebral blood flow and mean cerebral blood flow velocity in the infarcted area in the study group were higher than those in the Hemodynamics group,the indexes of specifi c impedance and cerebral vascular resistance were lower in the study group than those in the control group,the degree of neurological impairment in the study group was lower than that in the control group,and the level of activities of daily living(Adl)was higher than that in the control group(P<0.05).Conclusion Alteplase combined with butylphthalide can signifi cantly improve the cerebral vascular reserve function and hemodynamics function in patients with cerebral infarction.It can eff ectively alleviate the oxidative stress injury of patients,and is benefi cial to the improvement of neurological function and the improvement of the ability of daily living,with feasible treatment.