活性氧调控巨噬细胞极化的研究进展

巨噬细胞可以极化为两种表型:经典激活巨噬细胞(M1)和替代激活巨噬细胞(M2),前者分泌促炎细胞因子来促进炎性反应,而后者分泌炎性抑制因子抑制过量炎性反应、促进血管生成、组织修复和肿瘤生长等。作为重要的第二信使,活性氧(ROS)不仅导致促炎细胞因子的产生,而且促进肿瘤的发生和发展。在不同刺激条件下,ROS可调控巨噬细胞的极化过程,使其向不同表型转换,从而发挥不同作用。

Research progress of ROS in regulating macrophage polarization

Macrophages are divided into classically (M1) and alternatively (M2) activated macrophage phenotypes. The former secretes pro-inflammatory cytokines to amplify inflammation,while the latter secretes inflammation inhibition factors to inhibit excessive inflammation and promote angiogenesis,tissue repair,tumor growth and so on. As an important second messenger reactive oxygen species(ROS) not only leads to the production of proinflammatory cytokines,but also promotes the occurrence and development of cancer.Under different stimulating conditions,ROS can transform macrophage into different phenotypes by regulating the polarization process,and further play different roles.