2型糖尿病患者血浆脂联素浓度改变及其与胰岛素抵抗的关系

目的　了解 2型糖尿病患者血浆脂联素浓度的改变 ,并探讨与胰岛素抵抗的关系。方法　测定 64例 2型糖尿病和 3 0例正常对照组的血浆脂联素、空腹血糖 (FPG)、糖化血红蛋白 (HbA1c)、空腹血浆胰岛素 (FINS)、血脂、体重指数(BMI) ,计算胰岛素抵抗指数 (HOMA IR)及 β 细胞功能指数 (HOMA β)。比较脂联素浓度的改变 ,以及与其它因素的相关性。结果　正常对照组、非肥胖糖尿病组及肥胖糖尿病组 ,脂联素浓度依次降低 ,且均有统计学意义。大中血管并发症糖尿病组血浆脂联素水平较无大中血管并发症糖尿病组明显降低。在糖尿病患者中血浆脂联素与BMI、HOMA IR呈负相关 (P <0 0 5 ) ,与高密度脂蛋白胆固醇 (HDL c)呈正相关 (P <0 0 5 )。与FBG、HbA1c、甘油三酯 (TG)、总胆固醇 (TC)及 β 细胞功能指数 (HOMA β)相关性不明显。结论　 2型糖尿病患者血浆脂联素水平明显下降 ,并且与胰岛素抵抗有一定的相关性

Changs of plasma adiponectin concentration in type 2 diabetic patients and its relation to insulin resistanced

Objective: To investigate the changes of adiponectin and the relation to insulin resistance in type 2 diabetic mellitus(T_2DM). Methods: Blood samples from 64 patients with T_2DM and 30 participants were obtained to determine plasma levels of adiponectin, FPG, FINS, HbA1c, blood lipids and examine the associations between plasma levels of adiponectin and BMI, FINS, HOMA index and blood lipids. Results: Plasma levels of adiponectin was lower in T_2DM than in control subjects and the lowest in T_2DM with obesity. Plasma adiponectin levels were positively correlated with HDL cholesterol and negatively correlated with BMI, HOMA、IR. Conclusions: The plasma adiponectin levels are lower in T_2DM and relative to insulin resistance.